Protein IkB* map

Identifiers
HUGO:NFKBIA HUGO:NFKBIB HUGO:NFKBIE

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

References
 MACROPHAGE  map
 DENDRITIC_CELL  map
CASCADE:IL13
CASCADE:IL2
CASCADE:CSF2
CASCADE:TNF
PMID:23086447, PMID:25305492, PMID:23422957
In canonical NFkB pathway RelB/p50, RelA/p50 and c-Rel/p50 heterodimers are sequestered by IκB-α, IκB-β, and IκB-ε
PMID:10607713
Maturation of dendritic cells correlates with an increase in IκBα, IκBε, and Bcl-3
PMID:17550372, PMID:9743347
IL13 inhibits NFBB activation via inhibition of p65 nuclear migration in inflammatory macrophages and via prevention of degradation of IkBa (

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IkB*@INNATE_IMMUNE_CELL_Cytosol map
  2. IkB*|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IkB*:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  2. IkB*:​NFKB1_p50*:​RELB@INNATE_IMMUNE_CELL_Cytosol map
  3. IkB*:​NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map
  4. IkB*|​pho:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  5. IkB*|​pho:​NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map
  6. IL10RA:​IkB*|​pho:​NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. IkB*:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map → map IkB*|​pho:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  2. IkB*|​pho:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map + IkB*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. IkB*:​NFKB1_p50*:​RELB@INNATE_IMMUNE_CELL_Cytosol map → map IL10RA:​IkB*|​pho:​NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map
  4. IkB*:​NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map → map IkB*|​pho:​NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map
  5. IL10RA:​IkB*|​pho:​NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​RELB@INNATE_IMMUNE_CELL_Cytosol map + IkB*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  6. IkB*|​pho:​NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map + IkB*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  7. IkB*|​pho@INNATE_IMMUNE_CELL_Cytosol map → map degraded
  8. NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map + RELA@INNATE_IMMUNE_CELL_Cytosol map + IkB*@INNATE_IMMUNE_CELL_Cytosol map → map IkB*:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  9. NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map + RELB@INNATE_IMMUNE_CELL_Cytosol map + IkB*@INNATE_IMMUNE_CELL_Cytosol map → map IkB*:​NFKB1_p50*:​RELB@INNATE_IMMUNE_CELL_Cytosol map
  10. NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map + cREL*@INNATE_IMMUNE_CELL_Cytosol map + IkB*@INNATE_IMMUNE_CELL_Cytosol map → map IkB*:​NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser: