Protein NFKB1_p50* map

Identifiers
HUGO:NFKB1
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

Maps_Modules
 MACROPHAGE  map
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
CASCADE:IL2
CASCADE:CSF2
CASCADE:CSF1
CASCADE:TNF

References
PMID:19171876, PMID:17145890
NFkB p50/p50 homodimers (which lack the transactivation
domain) compete with canonical p65/p50 heterodimers for
the binding sites on the inflammatory
gene promoters, thereby blocking p65/p50 promoter
binding and gene transcription.
p50 NF-kappaB overexpression accounts for the
inability of tumor assasiated macrophages to mount
an effective M1 antitumor response capable of inhibiting tumor growth.
PMID:17404308
CSF1 downregulates TNF, IL-23p19, IL-12p40 expression probably via induction of acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map
  2. NFKB1_p50*|​hm2@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. BCL3:​NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map
  2. NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  3. NFKB1_p50*:​RELB@INNATE_IMMUNE_CELL_Cytosol map
  4. NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map
  5. NFKB1_p50*:​NFKBID@INNATE_IMMUNE_CELL_Cytosol map
  6. IkB*:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  7. IkB*:​NFKB1_p50*:​RELB@INNATE_IMMUNE_CELL_Cytosol map
  8. NFKB1_p50*:​RELA:​p100@INNATE_IMMUNE_CELL_Cytosol map
  9. CD247:​NFKB1_p50*:​p100@INNATE_IMMUNE_CELL_Cytosol map
  10. IkB*:​NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map
  11. IkB*|​pho:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  12. IkB*|​pho:​NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map
  13. IL10RA:​IkB*|​pho:​NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. BCL3@INNATE_IMMUNE_CELL_Cytosol map + NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map → map BCL3:​NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map
  2. NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map → map NFkB*@INNATE_IMMUNE_CELL_Cytosol map
  3. NFKB1_p50*:​RELB@INNATE_IMMUNE_CELL_Cytosol map → map NFkB*@INNATE_IMMUNE_CELL_Cytosol map
  4. NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map → map NFkB*@INNATE_IMMUNE_CELL_Cytosol map
  5. NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*|​hm2@INNATE_IMMUNE_CELL_Cytosol map
  6. IkB*:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map → map IkB*|​pho:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  7. IkB*|​pho:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map + IkB*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  8. IkB*:​NFKB1_p50*:​RELB@INNATE_IMMUNE_CELL_Cytosol map → map IL10RA:​IkB*|​pho:​NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map
  9. IkB*:​NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map → map IkB*|​pho:​NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map
  10. IL10RA:​IkB*|​pho:​NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​RELB@INNATE_IMMUNE_CELL_Cytosol map + IkB*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  11. IkB*|​pho:​NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map + IkB*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  12. NFKB1_p50*:​RELA:​p100@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map + p100@INNATE_IMMUNE_CELL_Cytosol map
  13. CD247:​NFKB1_p50*:​p100@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map + p100@INNATE_IMMUNE_CELL_Cytosol map
  14. NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map + RELA@INNATE_IMMUNE_CELL_Cytosol map + IkB*@INNATE_IMMUNE_CELL_Cytosol map → map IkB*:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  15. NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map + RELB@INNATE_IMMUNE_CELL_Cytosol map + IkB*@INNATE_IMMUNE_CELL_Cytosol map → map IkB*:​NFKB1_p50*:​RELB@INNATE_IMMUNE_CELL_Cytosol map
  16. NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map + cREL*@INNATE_IMMUNE_CELL_Cytosol map + IkB*@INNATE_IMMUNE_CELL_Cytosol map → map IkB*:​NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol map
  17. NFKBID@INNATE_IMMUNE_CELL_Cytosol map + NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​NFKBID@INNATE_IMMUNE_CELL_Cytosol map
  18. NFKB1_p105*@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. gTNF@INNATE_IMMUNE_CELL_Cytosol map → map rTNF@INNATE_IMMUNE_CELL_Cytosol map
  2. gBCL3@INNATE_IMMUNE_CELL_Cytosol map → map rBCL3@INNATE_IMMUNE_CELL_Cytosol map
  3. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol map → map rIL12p40*@INNATE_IMMUNE_CELL_Cytosol map
  4. gIL23A@INNATE_IMMUNE_CELL_Cytosol map → map rIL23A@INNATE_IMMUNE_CELL_Cytosol map