Protein SNCA
Modifications:
In compartment: Lewy body
- SNCA|S129_pho@Lewy body
- SNCA|S129_pho|ubi@Lewy body
- SNCA|S129_pho|ubi|ubi|ubi@Lewy body
In compartment: acidified vesicle
- SNCA@acidified vesicle
In compartment: astrocyte
- SNCA@astrocyte
In compartment: default
- SNCA@default
In compartment: docked synaptic vesicle
- SNCA@docked synaptic vesicle
In compartment: dopamine-loaded synaptic vesicle
- SNCA@dopamine-loaded synaptic vesicle
In compartment: early endosome
- SNCA|ubi|ubi|ubi@early endosome
In compartment: exosome
- SNCA@exosome
In compartment: fusing synaptic vesicle
- SNCA@fusing synaptic vesicle
In compartment: late endosome
- SNCA|ubi|ubi|ubi@late endosome
In compartment: lysosome
- SNCA@lysosome
- SNCA@lysosome
- SNCA|mutated A53T@lysosome
In compartment: mitochondrial matrix
- SNCA@mitochondrial matrix
- SNCA|mutated A53T@mitochondrial matrix
- SNCA|mutated E46K@mitochondrial matrix
In compartment: mitochondrion
- SNCA@mitochondrion
In compartment: multivesicular body
- SNCA@multivesicular body
In compartment: neuron
- SNCA@neuron
- SNCA|ubi@neuron
- SNCA|S129_pho@neuron
- SNCA|S129_ubi@neuron
- SNCA|mutated A30P@neuron
- SNCA|mutated A53T@neuron
- SNCA|L-dopaquinone@neuron
- SNCA|dopaminoquinone@neuron
- SNCA|ubi|ubi|ubi@neuron
In compartment: nucleus
- SNCA@nucleus
- SNCA|mutated A53T@nucleus
In compartment: phagosome
- SNCA@phagosome
Participates in complexes:
In compartment: neuron
- DNMT1:SNCA@neuron
- ATP1A3:SNCA@neuron
- PLK2:SNCA|S129_pho@neuron
Participates in reactions:
As Reactant or Product:- SNCA|ubi@neuron
→
degraded
- SNCA@fusing synaptic vesicle
→
arachidonic acid@neuron
- SNCA@default
→
arachidonic acid@neuron
- SNCA|mutated A30P@neuron
→
s3430
- SNCA|mutated A53T@neuron
→
s3430
- SNCA@mitochondrial matrix
→
ROS@neuron
- SNCA@neuron
→
SNCA@mitochondrion
- SNCA|mutated A53T@mitochondrial matrix
→
ROS@neuron
- SNCA|mutated A53T@mitochondrial matrix
→
mitochondrial fission@mitochondrial matrix
- SNCA|mutated E46K@mitochondrial matrix
→
mitochondrial fission@mitochondrial matrix
- SNCA@mitochondrial matrix
→
mitochondrial fission@mitochondrial matrix
- s812 →
SNCA@default
+ s12115 + GAPDH@default
+ PDCD6IP@default
+ ANXA2@default
+ FLOT1:FLOT2@default
+ HSP70@default
- dopaminoquinone@neuron
+ SNCA@neuron
→
SNCA|dopaminoquinone@neuron
- SNCA@neuron
+ L-dopaquinone@neuron
→
SNCA|L-dopaquinone@neuron
- SNCA|S129_pho@neuron
→
s10184
- SNCA@neuron
→
ERK1 and ERK2 cascade@neuron
- SNCA@neuron
→
Akt pathway@neuron
- SNCA@neuron
→
SNCA|ubi@neuron
- SNCA@neuron
→
SNCA|S129_pho@neuron
- PLK2@neuron
+ SNCA|S129_pho@neuron
→
PLK2:SNCA|S129_pho@neuron
- SNCA@lysosome
→
SNCA@lysosome
- PLK2:SNCA|S129_pho@neuron
→
SNCA@lysosome
- SNCA@lysosome
→
s7810
- SNCA@neuron
→
SNCA@lysosome
- SNCA@lysosome
→
s6159
- SNCA|mutated A53T@neuron
→
macroautophagy@neuron
- SNCA|dopaminoquinone@neuron
→
chaperone-mediated autophagy@lysosome
- SNCA|L-dopaquinone@neuron
→
chaperone-mediated autophagy@lysosome
- SNCA@neuron
→
Akt pathway@neuron
- SNCA@neuron
→
ERK1 and ERK2 cascade@neuron
- SNCA@nucleus
→
rPPARGC1A@nucleus
- SNCA@lysosome
+ s6157 →
degraded
- SNCA@neuron
→
SNCA@nucleus
- SNCA@nucleus
→
SNCA@neuron
- SNCA@nucleus
→
PPARGC1A|T295_pho|active@nucleus
- SNCA@nucleus
→
SNCA|S129_pho@neuron
- SNCA@nucleus
+ TP53@nucleus
→
rNOTCH1@nucleus
- SNCA@neuron
+ DNMT1@neuron
→
DNMT1:SNCA@neuron
- SNCA|ubi|ubi|ubi@neuron
→
SNCA|ubi|ubi|ubi@late endosome
- SNCA|ubi|ubi|ubi@neuron
→
SNCA|ubi|ubi|ubi@early endosome
- SNCA|ubi@neuron
→
SNCA|ubi|ubi|ubi@neuron
- SNCA|S129_ubi@neuron
→
HDAC6:HSF1|K80_ace:HSP40:HSP70:HSP90:PTGES3@neuron
- s3418 →
SNCA@neuron
- s9813 + ATP1A3@default
→
ATP1A3:SNCA@neuron
- SNCA@default
→
SNCA@phagosome
- SNCA@default
→
SNCA@phagosome
- SNCA@default
→
TLR2@microglia
- SNCA@default
→
TLR4@microglia
- SNCA@astrocyte
→
astrocyte activation@astrocyte
- SNCA@default
→
SNCA@astrocyte
- SNCA@neuron
→
PPP2CA:PPP2CB@neuron
- SNCA@neuron
→
s10184
- SNCA@neuron
→
SNCA|S129_pho@neuron
As Catalyser:- STX1A:STXBP1@neuron
+ SNAP25@neuron
+ VAMP2@dopamine-loaded synaptic vesicle
→
SNAP25:STX1A:STXBP1:VAMP2@docked synaptic vesicle
- generic protein|ubi|ubi|ubi@neuron
→
degraded + ubiquitin@neuron
- dopamine@fusing synaptic vesicle
→
dopamine@default
- mitophagy@neuron
→
neuron death@neuron
- NADH@mitochondrial matrix
+ ubiquinone@mitochondrial matrix
+ H+@mitochondrial matrix
→
NAD(+)@mitochondrial matrix
+ H+@mitochondrion
+ ubiquinol@mitochondrial matrix
- SNCA@lysosome
→
SNCA@lysosome
- SNCA@lysosome
→
s7810
- GBA@ER
→
GBA:PSAP@lysosome
- MEF2C@nucleus
→
MEF2C|SOH@nucleus
- MEF2C@nucleus
→
MEF2C|SNO@nucleus
- SNCA@neuron
→
SNCA@nucleus
- DNMT1@neuron
→
DNMT1@nucleus
- (ITGAM:ITGB2)|active@microglia
→
(ITGAM:ITGB2)|active@microglia
- s10184 →
s8542