Protein LRRK2
Modifications:
In compartment: Golgi
- LRRK2@Golgi
- LRRK2@Golgi
In compartment: Lewy body
- LRRK2@Lewy body
In compartment: Striatal Projection Neuron
- LRRK2@Striatal Projection Neuron
In compartment: dendritic shaft
- LRRK2@dendritic shaft
- LRRK2|mutated R1441C@dendritic shaft
In compartment: exosome
- LRRK2@exosome
- LRRK2|S1292_pho@exosome
In compartment: inclusion body
- LRRK2|mutated I2020T@inclusion body
- LRRK2|mutated Y1699C@inclusion body
- LRRK2|mutated R1441C/G/H@inclusion body
In compartment: lysosome
- LRRK2@lysosome
- LRRK2@lysosome
- LRRK2|mutated G2019S@lysosome
In compartment: microglia
- LRRK2@microglia
- LRRK2|S935_pho@microglia
- LRRK2|mutated R1441G@microglia
- LRRK2|mutated T2379M@microglia
- LRRK2|S935_pho|S910_pho@microglia
- LRRK2|active|mutated G2019S@microglia
In compartment: neuron
- LRRK2@neuron
- LRRK2|knock-out@neuron
- LRRK2|mutated G2385@neuron
- LRRK2|mutated I2020T@neuron
- LRRK2|mutated R1398H@neuron
- LRRK2|mutated R1441C@neuron
- LRRK2|mutated R1441G@neuron
- LRRK2|mutated Y1699C@neuron
- LRRK2|G2019S mutation@neuron
- LRRK2|mutated R1441C @neuron
- LRRK2|mutated R1441C/G/H@neuron
- LRRK2|S1292_pho|active@neuron
- LRRK2|active|mutated G2019S@neuron
- LRRK2|S935_pho|s1444_pho|S910_pho@neuron
In compartment: nucleus
- LRRK2|mutated G2019S@nucleus
In compartment: recycling endosome
- LRRK2@recycling endosome
Participates in complexes:
In compartment: ER
- LRRK2:SEC16A@ER
In compartment: Golgi
- GAK:LRRK2:RAB29@Golgi
In compartment: microglia
- LRRK2:NRON@microglia
In compartment: neuron
- LRRK2:PLEC@neuron
- DNM1L:LRRK2@neuron
- DNM1L:LRRK2@neuron
- GSK3B:LRRK2@neuron
- HSP90:LRRK2@neuron
- HSP90:LRRK2@neuron
- LRRK2:RAB5B@neuron
- DNM1L:LRRK2|mutated G2019S@neuron
- LRRK2|mutated G2019S:RAB7A@neuron
- LRRK2|mutated G2019S:YWHAQ@neuron
- 14-3-3:LRRK2|S935_pho|s1444_pho|S910_pho@neuron
- CTNNB1:DVL:FZD1:GSK3B:LRP5:LRP6:LRRK2:WNT3@neuron
In compartment: trans-Golgi network
- ARHGEF7:LRRK2@trans-Golgi network
Participates in reactions:
As Reactant or Product:- WNT3@default
+ FZD1@neuron
→
CTNNB1:DVL:FZD1:GSK3B:LRP5:LRP6:LRRK2:WNT3@neuron
- LRRK2|active|mutated G2019S@neuron
→
Endophilin A@neuron
- LRRK2@neuron
→
Endophilin A@neuron
- LRRK2@lysosome
+ GAPDH:RNASE1@lysosome
→
degraded
- LRRK2@lysosome
→
LRRK2@lysosome
- LRRK2@neuron
→
LRRK2@lysosome
- LRRK2@dendritic shaft
→
postsynaptic response@Striatal Projection Neuron
- PLEC@neuron
+ LRRK2@neuron
→
LRRK2:PLEC@neuron
- LRRK2:PLEC@neuron
→
actin filament organization@neuron
- LRRK2@neuron
→
TPCN2@lysosome
- LRRK2@neuron
→
cytosolic calcium ion homeostasis@neuron
- LRRK2|active|mutated G2019S@neuron
→
activation of LRRK2 protein kinase activity@neuron
- DNM1L@neuron
+ LRRK2@neuron
→
DNM1L:LRRK2@neuron
- DNM1L:LRRK2@neuron
→
DNM1L@mitochondrion
- LRRK2|mutated R1441G@microglia
→
neuron death@microglia
- LRRK2@microglia
→
inflammatory response@microglia
- LRRK2|S935_pho@microglia
→
s6779
- LRRK2@microglia
→
cytoskeleton organisation@microglia
- LRRK2@microglia
→
cell migration@microglia
- LRRK2@microglia
→
rNOS2@nucleus
- LRRK2@microglia
→
rTNF@nucleus
- LRRK2@microglia
→
Crohn disease@microglia
- LRRK2@microglia
→
s11098
- LRRK2@microglia
→
MAPK cascade@microglia
- LRRK2@microglia
→
inflammatory response@microglia
- LRRK2|mutated R1441G@microglia
→
LRRK2@microglia
- LRRK2@microglia
→
s11151
- LRRK2@microglia
→
rIL6@nucleus
- LRRK2|mutated T2379M@microglia
→
LRRK2@microglia
- LRRK2@microglia
→
LRRK2@microglia
- LRRK2@microglia
→
LRRK2|S935_pho@microglia
- LRRK2|active|mutated G2019S@neuron
→
mtDNA deletions@mitochondrial matrix
- LRRK2|active|mutated G2019S@neuron
→
mitochondrial membrane potential@mitochondrial matrix
- LRRK2|mutated R1441C@neuron
→
mtDNA deletions@mitochondrial matrix
- LRRK2|mutated R1441C@neuron
→
mitochondrial membrane potential@mitochondrial matrix
- LRRK2|active|mutated G2019S@neuron
+ DNM1L@neuron
→
DNM1L:LRRK2|mutated G2019S@neuron
- LRRK2@neuron
→
SQSTM1@neuron
- LRRK2@neuron
→
MAP1LC3B@neuron
- RAB7A@neuron
+ LRRK2|active|mutated G2019S@neuron
→
LRRK2|mutated G2019S:RAB7A@neuron
- RAB7A@neuron
+ LRRK2|active|mutated G2019S@neuron
→
LRRK2|mutated G2019S:RAB7A@neuron
- RAB5B@neuron
+ LRRK2@neuron
→
LRRK2:RAB5B@neuron
- LRRK2:RAB5B@neuron
→
neurite outgrowth@neuron
- LRRK2@neuron
+ DNM1L@neuron
→
DNM1L:LRRK2@neuron
- GAK@Golgi
+ LRRK2@Golgi
+ RAB29@Golgi
→
GAK:LRRK2:RAB29@Golgi
- GAK:LRRK2:RAB29@Golgi
→
vesicle sorting@neuron
- LRRK2|mutated R1441G@neuron
→
LRRK2@neuron
- LRRK2|mutated R1441C@neuron
→
LRRK2@neuron
- LRRK2|active|mutated G2019S@neuron
→
LRRK2@neuron
- LRRK2|mutated R1398H@neuron
→
LRRK2@neuron
- LRRK2|mutated G2385@neuron
→
LRRK2@neuron
- LRRK2|mutated R1398H@neuron
→
Parkinson's disease@neuron
- LRRK2@neuron
→
WNT signaling@neuron
- LRRK2|mutated I2020T@neuron
→
LRRK2@neuron
- LRRK2|active|mutated G2019S@neuron
→
LRRK2@neuron
- LRRK2|mutated Y1699C@neuron
→
LRRK2@neuron
- LRRK2|mutated R1441G@neuron
→
LRRK2@neuron
- LRRK2|active|mutated G2019S@neuron
→
LRRK2@neuron
- LRRK2|mutated R1441C@neuron
→
LRRK2@neuron
- LRRK2@neuron
+ GSK3B@neuron
→
GSK3B:LRRK2@neuron
- LRRK2|active|mutated G2019S@neuron
→
Tauopathies@neuron
- LRRK2|mutated R1441C@neuron
→
Tauopathies@neuron
- LRRK2|mutated I2020T@neuron
→
Tauopathies@neuron
- LRRK2|active|mutated G2019S@neuron
→
LRRK2@neuron
- LRRK2|active|mutated G2019S@neuron
→
GSK3B:LRRK2@neuron
- LRRK2|mutated R1441G@neuron
→
Parkinson's disease@neuron
- LRRK2|mutated Y1699C@neuron
→
Parkinson's disease@neuron
- LRRK2|active|mutated G2019S@neuron
→
Parkinson's disease@neuron
- LRRK2|mutated G2385@neuron
→
Parkinson's disease@neuron
- LRRK2@neuron
→
s7402
- LRRK2|knock-out@neuron
→
neurite outgrowth@neuron
- LRRK2|active|mutated G2019S@neuron
→
neurite outgrowth@neuron
- LRRK2@neuron
→
RAC1@neuron
- LRRK2|active|mutated G2019S@neuron
→
LRRK2@neuron
- RAC1@neuron
→
LRRK2|active|mutated G2019S@neuron
- LRRK2|active|mutated G2019S@neuron
→
LRRK2@neuron
- LRRK2|active|mutated G2019S@neuron
→
neurite outgrowth@neuron
- LRRK2@neuron
→
UPS@neuron
- LRRK2@neuron
→
s5133
- LRRK2@neuron
+ HSP90@neuron
→
HSP90:LRRK2@neuron
- LRRK2@neuron
→
degraded
- LRRK2|S935_pho|s1444_pho|S910_pho@neuron
+ YWHAE:YWHAG:YWHAQ:YWHAZ@neuron
→
14-3-3:LRRK2|S935_pho|s1444_pho|S910_pho@neuron
- LRRK2@neuron
→
LRRK2|S935_pho|s1444_pho|S910_pho@neuron
- LRRK2|mutated R1441C/G/H@neuron
→
LRRK2|mutated R1441C/G/H@inclusion body
- LRRK2|mutated Y1699C@neuron
→
LRRK2|mutated Y1699C@inclusion body
- LRRK2|mutated I2020T@neuron
→
LRRK2|mutated I2020T@inclusion body
- LRRK2@neuron
+ ARHGEF7@neuron
→
ARHGEF7:LRRK2@trans-Golgi network
- LRRK2|active|mutated G2019S@neuron
→
neurite outgrow@neuron
- LRRK2|mutated G2019S:YWHAQ@neuron
→
kinase activity@neuron
- HSP90@neuron
+ LRRK2@neuron
→
HSP90:LRRK2@neuron
- 14-3-3:LRRK2|S935_pho|s1444_pho|S910_pho@neuron
→
kinase activity@neuron
- LRRK2@neuron
→
LRRK2|S1292_pho|active@neuron
- LRRK2|active|mutated G2019S@neuron
→
kinase activity@neuron
- LRRK2|mutated I2020T@neuron
→
kinase activity@neuron
- LRRK2|mutated R1441C/G/H@neuron
→
GTPase activity@neuron
- LRRK2|mutated Y1699C@neuron
→
GTPase activity@neuron
- LRRK2|S1292_pho|active@neuron
→
LRRK2|S1292_pho@exosome
- LRRK2@neuron
→
LRRK2@exosome
- HSP90:LRRK2@neuron
→
UPS@neuron
- LRRK2|S1292_pho|active@neuron
→
kinase activity@neuron
- LRRK2|mutated R1398H@neuron
→
GTPase activity@neuron
- YWHAE:YWHAG:YWHAQ:YWHAZ@neuron
→
LRRK2|mutated R1441G@neuron
- YWHAE:YWHAG:YWHAQ:YWHAZ@neuron
+ LRRK2|active|mutated G2019S@neuron
→
LRRK2|mutated G2019S:YWHAQ@neuron
- LRRK2|active|mutated G2019S@neuron
→
proteolysis@neuron
- LRRK2|active|mutated G2019S@neuron
→
LRRK2@neuron
- LRRK2|active|mutated G2019S@neuron
→
LRRK2@neuron
- LRRK2|active|mutated G2019S@neuron
→
autophagy@neuron
- LRRK2|active|mutated G2019S@neuron
→
LRRK2@neuron
- LRRK2|mutated I2020T@neuron
→
LRRK2@neuron
- LRRK2|mutated G2019S@nucleus
→
s12091
- LRRK2@microglia
→
phagocytosis@microglia
- LRRK2@microglia
→
cell_space_chemotaxis@microglia
- LRRK2@microglia
→
LRRK2|S935_pho|S910_pho@microglia
- LRRK2@microglia
+ rNRON@microglia
→
LRRK2:NRON@microglia
- LRRK2|mutated Y1699C@neuron
→
LRRK2@neuron
- LRRK2@neuron
+ SEC16A@neuron
→
LRRK2:SEC16A@ER
- LRRK2:SEC16A@ER
→
ERES@ER
- LRRK2:SEC16A@ER
→
COPII@neuron
- LRRK2|mutated G2019S@nucleus
→
s9398
- LRRK2@neuron
→
NAPB:NSF@neuron
- LRRK2@neuron
→
NAPA:NSF@neuron
As Catalyser:- s1330 →
s1335
- s1338 →
s1332
- GSK3B@neuron
→
GSK3B|S9_pho@neuron
- CTNNB1@neuron
→
CTNNB1|pho@neuron
- MAP1LC3B|S12_pho@neuron
→
MAP1LC3B@neuron
- GRIA1:GRIA2:GRIA3:GRIA4@Striatal Projection Neuron
→
GRIA1|S845_pho:GRIA2:GRIA3:GRIA4|S842_pho@Striatal Projection Neuron
- s5388 →
s1330
- LAMP2@lysosome
→
s7820
- SNCA@lysosome
→
s7810
- CFL1:CFL2@dendritic spine
→
CFL1|S3_pho:CFL2|S3_pho@dendritic spine
- PRKACA:PRKACB:PRKACG@Striatal Projection Neuron
+ PRKAR2B@Striatal Projection Neuron
→
PKA catalytic subunit:PRKAR2B@dendritic shaft
- DNM1L@neuron
+ LRRK2@neuron
→
DNM1L:LRRK2@neuron
- (NFATC1:NFATC3)|active@microglia
→
(NFATC1:NFATC3)|active@nucleus
- (NFATC1:NFATC2)|active@microglia
→
(NFATC1:NFATC2)|active@nucleus
- DNM1L@neuron
→
DNM1L@neuron
- RAB7A@neuron
→
RAB7A@late endosome
- s1339 →
s1338
- RAB10@Golgi
→
RAB10|T73_pho@Golgi
- RAB8A@Golgi
→
RAB8A|T72_pho@Golgi
- AKT1@neuron
→
AKT1|S473_pho|active@neuron
- MAPT@microtubule
→
MAPT|pho|T181_pho@neuron
- (ACTR2:ACTR3)|active@neuron
+ globular actin|ATP:profilin@neuron
→
s11983
- PAK6@neuron
→
PAK6|T560_pho|active@neuron
- EZR:MSN:RDX@neuron
→
(EZR|pho:MSN|pho:RDX|pho)|active@neuron
- Alpha tubulin|K40_ace:TUBB:TUBB4A:TUBB6@microtubule
→
Alpha tubulin:TUBB4A:TUBB6:TUBB|pho@microtubule
- Alpha tubulin|K40_ace:TUBB:TUBB4A:TUBB6@microtubule
→
Alpha tubulin:TUBB4A:TUBB6:TUBB|pho@microtubule
- Alpha tubulin|K40_ace:TUBB:TUBB4A:TUBB6@microtubule
→
Alpha tubulin:TUBB4A:TUBB6:TUBB|pho@microtubule
- Alpha tubulin|K40_ace:TUBB:TUBB4A:TUBB6@microtubule
→
Alpha tubulin:TUBB4A:TUBB6:TUBB|pho@microtubule
- LRRK2@neuron
→
s5133
- LRRK2|S935_pho|s1444_pho|S910_pho@neuron
+ YWHAE:YWHAG:YWHAQ:YWHAZ@neuron
→
14-3-3:LRRK2|S935_pho|s1444_pho|S910_pho@neuron
- LRRK2@neuron
→
LRRK2|S1292_pho|active@neuron
- RPS15@neuron
→
RPS15|T136_pho@neuron
- EIF4EBP1@neuron
→
EIF4EBP1|pho@neuron
- AGO2@neuron
+ rmir-184*@neuron
+ rLet7@neuron
→
AGO2:miRNA@neuron
- EIF4EBP1|pho@neuron
+ AGO2@neuron
→
AGO2:EIF4EBP1|pho@neuron
- PTK2|Y397_pho|active@microglia
→
PTK2@microglia
- LRRK2@neuron
+ SEC16A@neuron
→
LRRK2:SEC16A@ER