Protein LRRK2  
 
Modifications:
In compartment: Golgi
- LRRK2@Golgi 
 
 - LRRK2@Golgi 
 
 
In compartment: Lewy body
- LRRK2@Lewy body 
 
 
In compartment: Striatal Projection Neuron
- LRRK2@Striatal Projection Neuron 
 
 
In compartment: dendritic shaft
- LRRK2@dendritic shaft 
 
 - LRRK2|mutated R1441C@dendritic shaft 
 
 
In compartment: exosome
- LRRK2@exosome 
 
 - LRRK2|S1292_pho@exosome 
 
 
In compartment: inclusion body
- LRRK2|mutated I2020T@inclusion body 
 
 - LRRK2|mutated Y1699C@inclusion body 
 
 - LRRK2|mutated R1441C/G/H@inclusion body 
 
 
In compartment: lysosome
- LRRK2@lysosome 
 
 - LRRK2@lysosome 
 
 - LRRK2|mutated G2019S@lysosome 
 
 
In compartment: microglia
- LRRK2@microglia 
 
 - LRRK2|S935_pho@microglia 
 
 - LRRK2|mutated R1441G@microglia 
 
 - LRRK2|mutated T2379M@microglia 
 
 - LRRK2|S935_pho|S910_pho@microglia 
 
 - LRRK2|active|mutated G2019S@microglia 
 
 
In compartment: neuron
- LRRK2@neuron 
 
 - LRRK2|knock-out@neuron 
 
 - LRRK2|mutated G2385@neuron 
 
 - LRRK2|mutated I2020T@neuron 
 
 - LRRK2|mutated R1398H@neuron 
 
 - LRRK2|mutated R1441C@neuron 
 
 - LRRK2|mutated R1441G@neuron 
 
 - LRRK2|mutated Y1699C@neuron 
 
 - LRRK2|G2019S mutation@neuron 
 
 - LRRK2|mutated R1441C @neuron 
 
 - LRRK2|mutated R1441C/G/H@neuron 
 
 - LRRK2|S1292_pho|active@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
 
 - LRRK2|S935_pho|s1444_pho|S910_pho@neuron 
 
 
In compartment: nucleus
- LRRK2|mutated G2019S@nucleus 
 
 
In compartment: recycling endosome
- LRRK2@recycling endosome 
 
 
Participates in complexes:
In compartment: ER
- LRRK2:SEC16A@ER 
 
 
In compartment: Golgi
- GAK:LRRK2:RAB29@Golgi 
 
 
In compartment: microglia
- LRRK2:NRON@microglia 
 
 
In compartment: neuron
- LRRK2:PLEC@neuron 
 
 - DNM1L:LRRK2@neuron 
 
 - DNM1L:LRRK2@neuron 
 
 - GSK3B:LRRK2@neuron 
 
 - HSP90:LRRK2@neuron 
 
 - HSP90:LRRK2@neuron 
 
 - LRRK2:RAB5B@neuron 
 
 - DNM1L:LRRK2|mutated G2019S@neuron 
 
 - LRRK2|mutated G2019S:RAB7A@neuron 
 
 - LRRK2|mutated G2019S:YWHAQ@neuron 
 
 - 14-3-3:LRRK2|S935_pho|s1444_pho|S910_pho@neuron 
 
 - CTNNB1:DVL:FZD1:GSK3B:LRP5:LRP6:LRRK2:WNT3@neuron 
 
 
In compartment: trans-Golgi network
- ARHGEF7:LRRK2@trans-Golgi network 
 
 
Participates in reactions:
As Reactant or Product:- WNT3@default 
  + FZD1@neuron 
  → 
  CTNNB1:DVL:FZD1:GSK3B:LRP5:LRP6:LRRK2:WNT3@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  Endophilin A@neuron 
 
 - LRRK2@neuron 
  → 
  Endophilin A@neuron 
 
 - LRRK2@lysosome 
  + GAPDH:RNASE1@lysosome 
  → 
  degraded
 - LRRK2@lysosome 
  → 
  LRRK2@lysosome 
 
 - LRRK2@neuron 
  → 
  LRRK2@lysosome 
 
 - LRRK2@dendritic shaft 
  → 
  postsynaptic response@Striatal Projection Neuron 
 
 - PLEC@neuron 
  + LRRK2@neuron 
  → 
  LRRK2:PLEC@neuron 
 
 - LRRK2:PLEC@neuron 
  → 
  actin filament organization@neuron 
 
 - LRRK2@neuron 
  → 
  TPCN2@lysosome 
 
 - LRRK2@neuron 
  → 
  cytosolic calcium ion homeostasis@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  activation of LRRK2 protein kinase activity@neuron 
 
 - DNM1L@neuron 
  + LRRK2@neuron 
  → 
  DNM1L:LRRK2@neuron 
 
 - DNM1L:LRRK2@neuron 
  → 
  DNM1L@mitochondrion 
 
 - LRRK2|mutated R1441G@microglia 
  → 
  neuron death@microglia 
 
 - LRRK2@microglia 
  → 
  inflammatory response@microglia 
 
 - LRRK2|S935_pho@microglia 
  → 
  s6779
 - LRRK2@microglia 
  → 
  cytoskeleton organisation@microglia 
 
 - LRRK2@microglia 
  → 
  cell migration@microglia 
 
 - LRRK2@microglia 
  → 
  rNOS2@nucleus 
 
 - LRRK2@microglia 
  → 
  rTNF@nucleus 
 
 - LRRK2@microglia 
  → 
  Crohn disease@microglia 
 
 - LRRK2@microglia 
  → 
  s11098
 - LRRK2@microglia 
  → 
  MAPK cascade@microglia 
 
 - LRRK2@microglia 
  → 
  inflammatory response@microglia 
 
 - LRRK2|mutated R1441G@microglia 
  → 
  LRRK2@microglia 
 
 - LRRK2@microglia 
  → 
  s11151
 - LRRK2@microglia 
  → 
  rIL6@nucleus 
 
 - LRRK2|mutated T2379M@microglia 
  → 
  LRRK2@microglia 
 
 - LRRK2@microglia 
  → 
  LRRK2@microglia 
 
 - LRRK2@microglia 
  → 
  LRRK2|S935_pho@microglia 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  mtDNA deletions@mitochondrial matrix 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  mitochondrial membrane potential@mitochondrial matrix 
 
 - LRRK2|mutated R1441C@neuron 
  → 
  mtDNA deletions@mitochondrial matrix 
 
 - LRRK2|mutated R1441C@neuron 
  → 
  mitochondrial membrane potential@mitochondrial matrix 
 
 - LRRK2|active|mutated G2019S@neuron 
  + DNM1L@neuron 
  → 
  DNM1L:LRRK2|mutated G2019S@neuron 
 
 - LRRK2@neuron 
  → 
  SQSTM1@neuron 
 
 - LRRK2@neuron 
  → 
  MAP1LC3B@neuron 
 
 - RAB7A@neuron 
  + LRRK2|active|mutated G2019S@neuron 
  → 
  LRRK2|mutated G2019S:RAB7A@neuron 
 
 - RAB7A@neuron 
  + LRRK2|active|mutated G2019S@neuron 
  → 
  LRRK2|mutated G2019S:RAB7A@neuron 
 
 - RAB5B@neuron 
  + LRRK2@neuron 
  → 
  LRRK2:RAB5B@neuron 
 
 - LRRK2:RAB5B@neuron 
  → 
  neurite outgrowth@neuron 
 
 - LRRK2@neuron 
  + DNM1L@neuron 
  → 
  DNM1L:LRRK2@neuron 
 
 - GAK@Golgi 
  + LRRK2@Golgi 
  + RAB29@Golgi 
  → 
  GAK:LRRK2:RAB29@Golgi 
 
 - GAK:LRRK2:RAB29@Golgi 
  → 
  vesicle sorting@neuron 
 
 - LRRK2|mutated R1441G@neuron 
  → 
  LRRK2@neuron 
 
 - LRRK2|mutated R1441C@neuron 
  → 
  LRRK2@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  LRRK2@neuron 
 
 - LRRK2|mutated R1398H@neuron 
  → 
  LRRK2@neuron 
 
 - LRRK2|mutated G2385@neuron 
  → 
  LRRK2@neuron 
 
 - LRRK2|mutated R1398H@neuron 
  → 
  Parkinson's disease@neuron 
 
 - LRRK2@neuron 
  → 
  WNT signaling@neuron 
 
 - LRRK2|mutated I2020T@neuron 
  → 
  LRRK2@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  LRRK2@neuron 
 
 - LRRK2|mutated Y1699C@neuron 
  → 
  LRRK2@neuron 
 
 - LRRK2|mutated R1441G@neuron 
  → 
  LRRK2@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  LRRK2@neuron 
 
 - LRRK2|mutated R1441C@neuron 
  → 
  LRRK2@neuron 
 
 - LRRK2@neuron 
  + GSK3B@neuron 
  → 
  GSK3B:LRRK2@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  Tauopathies@neuron 
 
 - LRRK2|mutated R1441C@neuron 
  → 
  Tauopathies@neuron 
 
 - LRRK2|mutated I2020T@neuron 
  → 
  Tauopathies@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  LRRK2@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  GSK3B:LRRK2@neuron 
 
 - LRRK2|mutated R1441G@neuron 
  → 
  Parkinson's disease@neuron 
 
 - LRRK2|mutated Y1699C@neuron 
  → 
  Parkinson's disease@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  Parkinson's disease@neuron 
 
 - LRRK2|mutated G2385@neuron 
  → 
  Parkinson's disease@neuron 
 
 - LRRK2@neuron 
  → 
  s7402
 - LRRK2|knock-out@neuron 
  → 
  neurite outgrowth@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  neurite outgrowth@neuron 
 
 - LRRK2@neuron 
  → 
  RAC1@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  LRRK2@neuron 
 
 - RAC1@neuron 
  → 
  LRRK2|active|mutated G2019S@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  LRRK2@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  neurite outgrowth@neuron 
 
 - LRRK2@neuron 
  → 
  UPS@neuron 
 
 - LRRK2@neuron 
  → 
  s5133
 - LRRK2@neuron 
  + HSP90@neuron 
  → 
  HSP90:LRRK2@neuron 
 
 - LRRK2@neuron 
  → 
  degraded
 - LRRK2|S935_pho|s1444_pho|S910_pho@neuron 
  + YWHAE:YWHAG:YWHAQ:YWHAZ@neuron 
  → 
  14-3-3:LRRK2|S935_pho|s1444_pho|S910_pho@neuron 
 
 - LRRK2@neuron 
  → 
  LRRK2|S935_pho|s1444_pho|S910_pho@neuron 
 
 - LRRK2|mutated R1441C/G/H@neuron 
  → 
  LRRK2|mutated R1441C/G/H@inclusion body 
 
 - LRRK2|mutated Y1699C@neuron 
  → 
  LRRK2|mutated Y1699C@inclusion body 
 
 - LRRK2|mutated I2020T@neuron 
  → 
  LRRK2|mutated I2020T@inclusion body 
 
 - LRRK2@neuron 
  + ARHGEF7@neuron 
  → 
  ARHGEF7:LRRK2@trans-Golgi network 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  neurite outgrow@neuron 
 
 - LRRK2|mutated G2019S:YWHAQ@neuron 
  → 
  kinase activity@neuron 
 
 - HSP90@neuron 
  + LRRK2@neuron 
  → 
  HSP90:LRRK2@neuron 
 
 - 14-3-3:LRRK2|S935_pho|s1444_pho|S910_pho@neuron 
  → 
  kinase activity@neuron 
 
 - LRRK2@neuron 
  → 
  LRRK2|S1292_pho|active@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  kinase activity@neuron 
 
 - LRRK2|mutated I2020T@neuron 
  → 
  kinase activity@neuron 
 
 - LRRK2|mutated R1441C/G/H@neuron 
  → 
  GTPase activity@neuron 
 
 - LRRK2|mutated Y1699C@neuron 
  → 
  GTPase activity@neuron 
 
 - LRRK2|S1292_pho|active@neuron 
  → 
  LRRK2|S1292_pho@exosome 
 
 - LRRK2@neuron 
  → 
  LRRK2@exosome 
 
 - HSP90:LRRK2@neuron 
  → 
  UPS@neuron 
 
 - LRRK2|S1292_pho|active@neuron 
  → 
  kinase activity@neuron 
 
 - LRRK2|mutated R1398H@neuron 
  → 
  GTPase activity@neuron 
 
 - YWHAE:YWHAG:YWHAQ:YWHAZ@neuron 
  → 
  LRRK2|mutated R1441G@neuron 
 
 - YWHAE:YWHAG:YWHAQ:YWHAZ@neuron 
  + LRRK2|active|mutated G2019S@neuron 
  → 
  LRRK2|mutated G2019S:YWHAQ@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  proteolysis@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  LRRK2@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  LRRK2@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  autophagy@neuron 
 
 - LRRK2|active|mutated G2019S@neuron 
  → 
  LRRK2@neuron 
 
 - LRRK2|mutated I2020T@neuron 
  → 
  LRRK2@neuron 
 
 - LRRK2|mutated G2019S@nucleus 
  → 
  s12091
 - LRRK2@microglia 
  → 
  phagocytosis@microglia 
 
 - LRRK2@microglia 
  → 
  cell_space_chemotaxis@microglia 
 
 - LRRK2@microglia 
  → 
  LRRK2|S935_pho|S910_pho@microglia 
 
 - LRRK2@microglia 
  + rNRON@microglia 
  → 
  LRRK2:NRON@microglia 
 
 - LRRK2|mutated Y1699C@neuron 
  → 
  LRRK2@neuron 
 
 - LRRK2@neuron 
  + SEC16A@neuron 
  → 
  LRRK2:SEC16A@ER 
 
 - LRRK2:SEC16A@ER 
  → 
  ERES@ER 
 
 - LRRK2:SEC16A@ER 
  → 
  COPII@neuron 
 
 - LRRK2|mutated G2019S@nucleus 
  → 
  s9398
 - LRRK2@neuron 
  → 
  NAPB:NSF@neuron 
 
 - LRRK2@neuron 
  → 
  NAPA:NSF@neuron 
 
 
As Catalyser:- s1330 → 
  s1335
 - s1338 → 
  s1332
 - GSK3B@neuron 
  → 
  GSK3B|S9_pho@neuron 
 
 - CTNNB1@neuron 
  → 
  CTNNB1|pho@neuron 
 
 - MAP1LC3B|S12_pho@neuron 
  → 
  MAP1LC3B@neuron 
 
 - GRIA1:GRIA2:GRIA3:GRIA4@Striatal Projection Neuron 
  → 
  GRIA1|S845_pho:GRIA2:GRIA3:GRIA4|S842_pho@Striatal Projection Neuron 
 
 - s5388 → 
  s1330
 - LAMP2@lysosome 
  → 
  s7820
 - SNCA@lysosome 
  → 
  s7810
 - CFL1:CFL2@dendritic spine 
  → 
  CFL1|S3_pho:CFL2|S3_pho@dendritic spine 
 
 - PRKACA:PRKACB:PRKACG@Striatal Projection Neuron 
  + PRKAR2B@Striatal Projection Neuron 
  → 
  PKA catalytic subunit:PRKAR2B@dendritic shaft 
 
 - DNM1L@neuron 
  + LRRK2@neuron 
  → 
  DNM1L:LRRK2@neuron 
 
 - (NFATC1:NFATC3)|active@microglia 
  → 
  (NFATC1:NFATC3)|active@nucleus 
 
 - (NFATC1:NFATC2)|active@microglia 
  → 
  (NFATC1:NFATC2)|active@nucleus 
 
 - DNM1L@neuron 
  → 
  DNM1L@neuron 
 
 - RAB7A@neuron 
  → 
  RAB7A@late endosome 
 
 - s1339 → 
  s1338
 - RAB10@Golgi 
  → 
  RAB10|T73_pho@Golgi 
 
 - RAB8A@Golgi 
  → 
  RAB8A|T72_pho@Golgi 
 
 - AKT1@neuron 
  → 
  AKT1|S473_pho|active@neuron 
 
 - MAPT@microtubule 
  → 
  MAPT|pho|T181_pho@neuron 
 
 - (ACTR2:ACTR3)|active@neuron 
  + globular actin|ATP:profilin@neuron 
  → 
  s11983
 - PAK6@neuron 
  → 
  PAK6|T560_pho|active@neuron 
 
 - EZR:MSN:RDX@neuron 
  → 
  (EZR|pho:MSN|pho:RDX|pho)|active@neuron 
 
 - Alpha tubulin|K40_ace:TUBB:TUBB4A:TUBB6@microtubule 
  → 
  Alpha tubulin:TUBB4A:TUBB6:TUBB|pho@microtubule 
 
 - Alpha tubulin|K40_ace:TUBB:TUBB4A:TUBB6@microtubule 
  → 
  Alpha tubulin:TUBB4A:TUBB6:TUBB|pho@microtubule 
 
 - Alpha tubulin|K40_ace:TUBB:TUBB4A:TUBB6@microtubule 
  → 
  Alpha tubulin:TUBB4A:TUBB6:TUBB|pho@microtubule 
 
 - Alpha tubulin|K40_ace:TUBB:TUBB4A:TUBB6@microtubule 
  → 
  Alpha tubulin:TUBB4A:TUBB6:TUBB|pho@microtubule 
 
 - LRRK2@neuron 
  → 
  s5133
 - LRRK2|S935_pho|s1444_pho|S910_pho@neuron 
  + YWHAE:YWHAG:YWHAQ:YWHAZ@neuron 
  → 
  14-3-3:LRRK2|S935_pho|s1444_pho|S910_pho@neuron 
 
 - LRRK2@neuron 
  → 
  LRRK2|S1292_pho|active@neuron 
 
 - RPS15@neuron 
  → 
  RPS15|T136_pho@neuron 
 
 - EIF4EBP1@neuron 
  → 
  EIF4EBP1|pho@neuron 
 
 - AGO2@neuron 
  + rmir-184*@neuron 
  + rLet7@neuron 
  → 
  AGO2:miRNA@neuron 
 
 - EIF4EBP1|pho@neuron 
  + AGO2@neuron 
  → 
  AGO2:EIF4EBP1|pho@neuron 
 
 - PTK2|Y397_pho|active@microglia 
  → 
  PTK2@microglia 
 
 - LRRK2@neuron 
  + SEC16A@neuron 
  → 
  LRRK2:SEC16A@ER