Identifiers
PolB, polymerase (DNA directed), beta
HUGO:POLB HGNC:9174 ENTREZ:5423 UNIPROT:P06746 GENECARDS:POLB REACTOME:53846 KEGG:11232 ATLASONC:GC_POLB WIKI:POLB

Maps_Modules
 dnarepair 

References
PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013
POLB is important for repair of ROS-induced DNA damage, inhibiting impoves sensitivity to ROS-like drugs
PMID:20510258, PMID:21251944

References
d_re2:( dnarepair  ) deoxyribose-phosphatase activity of PolB
d_re7:( dnarepair  ) deoxyribose 5'-phosphatase activity of PolB
d_re22( dnarepair  ):
PMID:18398454
PMID:16449207
RECQL5 activates BER via XRCC1 and PARP1
PMID:22973052

1. POLB@default

1. PARP2|​unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default
2. PARP1|​PolyADPribose_unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default
3. PARP1:​PCNA:​POLB:​POLD*:​POLE*:​RFC*@default

1. POLB@default + PCNA@default + POLE*@default + POLD*@default + PARP1|​PolyADPribose_unk|​pho@Nucleus + RFC*@Nucleus → PARP1:​PCNA:​POLB:​POLD*:​POLE*:​RFC*@default
2. POLB@default + XRCC1|​pho@default + PARP1|​PolyADPribose_unk|​pho@Nucleus + WRN|​ace@default + PNK*@default → PARP1|​PolyADPribose_unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default
3. PARP2|​unk|​pho@default + WRN|​ace@default + PNK*@default + XRCC1|​pho@default + POLB@default → PARP2|​unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default

1. gBER_M-glyc_DNA_st3*@Nucleus → gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus + 5'dRP@default
2. gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus + dNTPs@Nucleus → gShP_BER_M-glyc_st5_B-glyc_DNA_st5*@Nucleus
3. gBER_M-glyc_DNA_st3*@Nucleus + dNTPs@default → gLnP_BER_M-glyc_st4*@Nucleus
4. gBER_B-glyc_DNA_st2*@Nucleus → gBER_B-glyc_DNA_st3*@Nucleus