Identifiers
poly (ADP-ribose) polymerase 2
HUGO:PARP2 HGNC:272 ENTREZ:10038 UNIPROT:Q9UGN5 GENECARDS:PARP2 KEGG:10038 ATLASONC:GC_PARP2 WIKI:PARP2
Q9UGN5
Maps_Modules
dnarepair
dnarepair
dnarepair
dnarepair
dnarepair
References
NOTE:
PARP-? poly-ADP-ribosilated
PMID:22055391
PARP is active phosphorylated and poly-ADP-ribosilated form
PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072
PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce
PMID:22921416
PARPs in cellular functions
PMID:22713970
PARP1 and PARP2 in HR and in inhibition of C_NHEJ
PMID:22469522, PMID:196269035
PARP2 in chromatin remodeling
PMID:22469522, PMID:22713970
References
d_re105( dnarepair ):
PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224
For inhibition of A_NHEJ by DNA-PKs:
PMID:15211575
For stimulation of A_NHEJ by PARP1:
PMID:15498778, PMID:19362533, PMID:24050180
For role of MRN complex in A_NHEJ:
PMID:19654615, PMID:19892829
BLM inhibits A_NHEJ (alt_NHEJ):
PMID:24089143
PMID:24095737
d_re545( dnarepair ):
PMID:18398454
PMID:16449207
d_re549( dnarepair ):
PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce
PMID:22921416
+ MRE11*:NBS1*|S343_pho:RAD50@default + PARP1|PolyADPribose_unk|pho:PARP2|unk|pho@default → BRCA1:CTIP*|emp|S372_pho|T847_pho|S267_pho|BRCA1-dep_ubi:MRE11*:NBS1*|S343_pho:PARP1|PolyADPribose_unk|pho:PARP2|unk|pho:RAD50@default
→ PARP2@default
→ PARP2|unk|pho@default
+ WRN|ace@default + PNK*@default + XRCC1|pho@default + POLB@default → PARP2|unk|pho:PNK*:POLB:WRN|ace:XRCC1|pho@default
→ Oxidative stress@Nucleus
→ Mitochondria metabolism@Nucleus
+ PARP1|PolyADPribose_unk|pho@Nucleus → PARP1|PolyADPribose_unk|pho:PARP2|unk|pho@default
→ Telomere maintenance@Nucleus
→ Chromatin remodeling@Nucleus