Complex Ku70*:Ku80* map
Complex composition:

  1. Ku80* map
  2. Ku70* map

Ku70*:​Ku80*@Nucleus

Identifiers
NAME:Ku70*:Ku80*

Maps_Modules
 dnarepair  map

References
The complex presents in double amount to cover both ends of broken DNA double helix
Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ
PMID:17088286
d_re79:( dnarepair  map ) PMID:19772495
d_re80( dnarepair  map ):
The complex MRN:BRCA1:phos-Ub-CtIP is central in the shift toward HR, because it activates resection for HR and blocks Ku70/80 of C_NHEJ:
PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983
d_re95:( dnarepair  map ) PMID:11955432, PMID:19772495
d_re105( dnarepair  map ):
PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224
For inhibition of A_NHEJ by DNA-PKs:
PMID:15211575
For stimulation of A_NHEJ by PARP1:
PMID:15498778, PMID:19362533, PMID:24050180
For role of MRN complex in A_NHEJ:
PMID:19654615, PMID:19892829
BLM inhibits A_NHEJ (alt_NHEJ):
PMID:24089143
PMID:24095737
d_re374( dnarepair  map ):
PMID:17962814
Link between spindle checkpoint and ds break DNA repair pathway (C_NHEJ)

Confidence
REF=5 FUNC=5

Modifications:
Participates in complexes:
In compartment: Nucleus
  1. Ku70*:​Ku80*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. Ku70*:​Ku80*@Nucleus map + Securin*@default map → map Ku70*:​Ku80*:​Securin*@default map
  2. Ku70*@default map + Ku80*@default map → map Ku70*:​Ku80*@Nucleus map
  3. DNA-PK*|​hm2|​active@default map + Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@default map + Ku70*:​Ku80*@Nucleus map + PARP3@Nucleus map → map Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map
As Catalyser:
  1. gA_NHEJ_DNA_st1*@Nucleus map → map gA_NHEJ_DNA_st2*@Nucleus map
  2. gC_NHEJ_DNA_st1*@Nucleus map → map gC_NHEJ_DNA_st2*@Nucleus map