Protein Ku70* map

Identifiers
X-ray repair complementing defective repair in Chinese hamster cells 6
HUGO:XRCC6 HGNC:4055 ENTREZ:2547 UNIPROT:P12956 GENECARDS:XRCC6 REACTOME:58273 KEGG:2547 ATLASONC:XRCC6ID246ch22q13 WIKI:XRCC6

Maps_Modules
 apoptosis  map
 apoptosis  map
 dnarepair  map

References
PMID:20691907, PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258,
PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:24050180
Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ
PMID:17088286

Ku70*@Nucleus

References
d_re85:( dnarepair  map ) PMID:9242410

Ku70*@default

References
d_re79:( dnarepair  map ) PMID:19772495
d_re566( dnarepair  map ):
Binding between Ku70/80/DNA-PK and WRN inhibits Ku activity
PMID:17303082
PMID:12202749
WRN is a key activator of alt_NHEJ pathway
PMID:18524993
C_NHEJ and A_NHEJ are competing mechanisms
PMID:24050180

Modifications:
In compartment: Nucleus
  1. Ku70*@Nucleus map
In compartment: default
  1. Ku70*@default map
Participates in complexes:
In compartment: Nucleus
  1. Ku70*:​Ku80*@Nucleus map
  2. DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus map
  3. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map
  4. APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus map
In compartment: default
  1. Ku70*:​Ku80*:​Securin*@default map
Participates in reactions:
As Reactant or Product:
  1. Ku70*:​Ku80*@Nucleus map + Securin*@default map → map Ku70*:​Ku80*:​Securin*@default map
  2. Ku80*@default map + Ku70*@default map + WRN@Nucleus map + DNA-PK*@default map → map DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus map
  3. Ku70*@default map + Ku80*@default map → map Ku70*:​Ku80*@Nucleus map
  4. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@default map + LIG4:​XLF*:​XRCC4|​hm2@default map + PARP3@Nucleus map + DNA-PK*|​hm2|​active@default map + Ku80*@default map + Ku70*@Nucleus map + APLF@Nucleus map → map APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus map
  5. DNA-PK*|​hm2|​active@default map + Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@default map + Ku70*:​Ku80*@Nucleus map + PARP3@Nucleus map → map Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map
As Catalyser:
  1. gA_NHEJ_DNA_st1*@Nucleus map → map gA_NHEJ_DNA_st2*@Nucleus map
  2. gC_NHEJ_DNA_st1*@Nucleus map → map gC_NHEJ_DNA_st2*@Nucleus map
  3. gC_NHEJ_DNA_st3*@Nucleus map → map gC_NHEJ_DNA_st4*@Nucleus map
  4. gC_NHEJ_DNA_st4*@Nucleus map → map gC_NHEJ_DNA_st5*@Nucleus map