Protein DNA-PK* map

Identifiers
protein kinase, DNA-activated, catalytic polypeptide
HUGO:PRKDC HGNC:9413 ENTREZ:5591 UNIPROT:P78527 GENECARDS:PRKDC REACTOME:62162 KEGG:5591 ATLASONC:GC_PRKDC WIKI:PRKDC

Maps_Modules
 apoptosis  map
 dnarepair  map

References
PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:21376743
PMID:21300785, PMID:21175350, PMID:20691907

DNA-PK*|​pho@default

References
d_re82:( dnarepair  map ) PMID:21376743

DNA-PK*|​hm2|​active@default

References
d_re85:( dnarepair  map ) PMID:9242410
d_re95:( dnarepair  map ) PMID:11955432, PMID:19772495
d_re132:( dnarepair  map ) PMID:19841479, PMID:19793861
d_re383:( dnarepair  map ) PMID:9892021

DNA-PK*@default

References
d_re43:( dnarepair  map ) PMID:16731533
d_re82:( dnarepair  map ) PMID:21376743
d_re90( dnarepair  map ):
PMID:9488723, PMID:19772495
PMID:17303408
d_re94:( dnarepair  map ) PMID:16093244
d_re566( dnarepair  map ):
Binding between Ku70/80/DNA-PK and WRN inhibits Ku activity
PMID:17303082
PMID:12202749
WRN is a key activator of alt_NHEJ pathway
PMID:18524993
C_NHEJ and A_NHEJ are competing mechanisms
PMID:24050180

Modifications:
In compartment: Nucleus
  1. DNA-PK*@Nucleus map
In compartment: default
  1. DNA-PK*@default map
  2. DNA-PK*|​pho@default map
  3. DNA-PK*|​hm2|​active@default map
Participates in complexes:
In compartment: Nucleus
  1. DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus map
  2. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map
  3. APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. Ku80*@default map + Ku70*@default map + WRN@Nucleus map + DNA-PK*@default map → map DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus map
  2. DNA-PK*@default map → map DNA-PK*|​pho@default map
  3. DNA-PK*@default map → map DNA-PK*|​hm2|​active@default map
  4. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@default map + LIG4:​XLF*:​XRCC4|​hm2@default map + PARP3@Nucleus map + DNA-PK*|​hm2|​active@default map + Ku80*@default map + Ku70*@Nucleus map + APLF@Nucleus map → map APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus map
  5. DNA-PK*|​hm2|​active@default map + Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@default map + Ku70*:​Ku80*@Nucleus map + PARP3@Nucleus map → map Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map
As Catalyser:
  1. gA_NHEJ_DNA_st1*@Nucleus map → map gA_NHEJ_DNA_st2*@Nucleus map
  2. SMARCAL1@default map → map SMARCAL1|​pho@default map
  3. Securin*@default map → map Securin*|​S165_pho@default map
  4. RPA2@default map → map RPA2|​pho@default map
  5. gC_NHEJ_DNA_st3*@Nucleus map → map gC_NHEJ_DNA_st4*@Nucleus map
  6. DNA-PK*@default map → map DNA-PK*|​pho@default map
  7. H2AFX@default map → map H2AFX|​S139_pho@default map
  8. Artemis*@default map → map Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@default map
  9. gC_NHEJ_DNA_st4*@Nucleus map → map gC_NHEJ_DNA_st5*@Nucleus map