Reaction state_transition d_re187 map

FANCD2@default map → FANCD2|​pho@default map

Reaction regulators:
Boolean_logic_gate_and
  1. ATR|​pho|​active@Nucleus map and MRE11*:​NBS1*|​S343_pho:​RAD50@default map and BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map
Catalysis
  1. MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  2. CHEK1|​pho|​active@default map
  3. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map
  4. ATR|​pho|​active@Nucleus map
Physical_stimulation
  1. NBS1*|​S343_pho@default map
Trigger
  1. gFanconi_DNA_st1*@Nucleus map


References
PMID:18931676, PMID:19686080
Link between cell cycle and activation of Fanconi pathway
NBS1 is required for FANCD2 phosphorylation and relocation into the FA core complex:
PMID:14988723

Confidence
REF=2 FUNC=4