Protein NBS1* map

Identifiers
nibrin
HUGO:NBN HGNC:7652 ENTREZ:4683 UNIPROT:O60934 GENECARDS:NBN REACTOME:75162 KEGG:4683 ATLASONC:NBS1ID160 WIKI:NBN

Maps_Modules
 apoptosis  map
 dnarepair  map
 dnarepair  map
 dnarepair  map
 dnarepair  map
 cellcycle  map

References
PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763
For S-phase checkpoint
PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003
For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ):
PMID:21376743, PMID:24050180, PMID:22743550

NBS1*@default

References
d_re205( dnarepair  map ):
Phosphorylation of NBS1 by ATR in response to crosslink-activation of S phase checkpoint
PMID:15136767, PMID:14988723

NBS1*|​S343_pho@default

References
d_re205( dnarepair  map ):
Phosphorylation of NBS1 by ATR in response to crosslink-activation of S phase checkpoint
PMID:15136767, PMID:14988723
d_re91( dnarepair  map ):
MRN complex:
PMID:16531125, PMID:17303408
Double strand breaks sensor.
MRN complex association is a first event after the DNA damage.
d_re166( dnarepair  map ):
Fanconi recognition complex as FA core complex recruits NER, HR, TLS proteins that collectively repair the ICL. If Fanconi proteins participating in the recognition are dysactivated, there is no any other mechanism to recognize ILSs, therefore, even if NER, HR and TLS are correct, they will not perform the repair without core Fanconi proteins.
PMID:19686080
d_re187( dnarepair  map ):
PMID:18931676, PMID:19686080
Link between cell cycle and activation of Fanconi pathway
NBS1 is required for FANCD2 phosphorylation and relocation into the FA core complex:
PMID:14988723

Modifications:
In compartment: default
  1. NBS1*@default map
  2. NBS1*|​S343_pho@default map
Participates in complexes:
In compartment: Nucleus
  1. ATM|​S1981_pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​MRE11*:​NBS1*|​S343_pho:​RAD50:​WRN@Nucleus map
In compartment: default
  1. MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  2. ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  3. ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  4. ATM|​S1981_pho|​S367_pho|​S1893_pho:​H2AFX|​S139_pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  5. BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default map
  6. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  7. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
Participates in reactions:
As Reactant or Product:
  1. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@default map → map BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default map
  2. ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map + CTIP*|​emp@default map + WRN@Nucleus map → map ATM|​S1981_pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​MRE11*:​NBS1*|​S343_pho:​RAD50:​WRN@Nucleus map
  3. FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default map + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map + BRCA2@default map + NBS1*|​S343_pho@default map + RAD51@default map + PCNA@default map + H2AFX|​S139_pho|​ubi@default map + TIP60*@default map → map BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  4. NBS1*@default map → map NBS1*|​S343_pho@default map
  5. FANCD2|​K561_ubi|​pho@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + ATR|​pho|​active@Nucleus map → map ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  6. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map → map BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  7. MRE11*@default map + RAD50@default map + NBS1*|​S343_pho@default map → map MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  8. ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map + H2AFX|​S139_pho|​ubi:​MDC1|​pho@default map → map ATM|​S1981_pho|​S367_pho|​S1893_pho:​H2AFX|​S139_pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  9. ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map → map ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
As Catalyser:
  1. gA_NHEJ_DNA_st1*@Nucleus map → map gA_NHEJ_DNA_st2*@Nucleus map
  2. gHR_DNA_st1*@Nucleus map → map gHR_DNA_st2*@Nucleus map
  3. G1 phase@default map → map S phase@default map
  4. S phase@default map → map G2 phase@default map
  5. G2 phase@default map → map M phase@default map
  6. gHR_DNA_st2*@Nucleus map → map gHR_DNA_st3*@Nucleus map
  7. gFanconi_DNA_st2*@Nucleus map → map gFanconi_DNA_st3*@Nucleus map
  8. gFanconi_DNA_st3*@Nucleus map → map gFanconi_DNA_st4*@Nucleus map
  9. gFanconi_DNA_st4*@Nucleus map → map gHR_DNA_st2*@Nucleus map
  10. FANCD2@default map → map FANCD2|​pho@default map
  11. gSSA_DNA_st1*@Nucleus map → map gSSA_DNA_st2*@Nucleus map
  12. ATM@default map → map ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@default map
  13. CHEK2@default map → map CHEK2|​pho|​active@default map
  14. Ku70*@default map + Ku80*@default map → map Ku70*:​Ku80*@Nucleus map
  15. gC_NHEJ_DNA_st1*@Nucleus map → map gC_NHEJ_DNA_st2*@Nucleus map
  16. DNA-PK*@default map → map DNA-PK*|​pho@default map
  17. H2AFX@default map → map H2AFX|​S139_pho@default map