Reaction heterodimer_association d_re355 map

ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*@default map + MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7@default map + CDT1@default map + CDC6@default map + CDC45@default map + POLA*@default map + PRIM*@default map + RPA1@Nucleus map + RPA2@Nucleus map + RPA3@Nucleus map → CDC45:​CDC6:​CDT1:​MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7:​ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*:​POLA*:​PRIM*:​RPA1:​RPA2:​RPA3@default map

Reaction regulators:
Catalysis
  1. PP2A*@default map
  2. CDC7:​DBF4@default map
  3. (CDK2|​T160_pho:​CyclinE*)|​active@default map
  4. (CDK2|​T160_pho:​CyclinA1*)|​active@default map
  5. (CDK1|​Y14/15_pho|​T161_pho:​CyclinA1*)|​active@default map
  6. RPA1:​RPA2:​RPA3@default map
Inhibition
  1. HUS1:​RAD1:​RAD17:​RAD9*:​RFC*@default map
  2. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3:​TIM1*:​TIPIN@default map


References
For role of TIM1*/TIPIN in S-phase checkpoint, replication arrest, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221

Confidence
REF=3 FUNC=3