Protein RPA1
Identifiers
replication protein A1, 70kDa
HUGO:RPA1 HGNC:10289 ENTREZ:6117 UNIPROT:P27694 GENECARDS:RPA1 REACTOME:99862 KEGG:6117 ATLASONC:GC_RPA1 WIKI:RPA1
Maps_Modules
dnarepair
dnarepair
dnarepair
dnarepair
dnarepair
References
PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249
For S-phase checkpoint
PMID:15459660, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104
RPA1@Nucleus
References
d_re355( dnarepair
):
For role of TIM1*/TIPIN in S-phase checkpoint, replication arrest, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
Modifications:
In compartment: Nucleus
- RPA1@Nucleus
In compartment: default
- RPA1@default
Participates in complexes:
In compartment: Nucleus
- EXO1:PCNA:RFC*:RPA1:RPA2:RPA3:hMutL*:hMutS*@Nucleus
In compartment: default
- RPA1:RPA2:RPA3@default
- RPA1:RPA2|pho:RPA3@default
- POLD*:RPA1:RPA2|pho:RPA3@default
- RAD52:RPA1:RPA2|pho:RPA3@default
- RPA1:RPA2:RPA3:SMARCAL1|pho@default
- ATRIP:ATR|pho:CLSPN|pho:RPA1:RPA2:RPA3@default
- BRCA1:BRCA2:FANCD2|pho:FANCI|pho:FANCJ*:FANCN*:RPA1:RPA2:RPA3@default
- ATRIP:ATR|pho:CHEK1|pho:CLSPN|pho:RPA1:RPA2:RPA3:TIM1*:TIPIN@default
- BRCA1:BRCA2:FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho:FANCJ*:FANCN*:RPA1:RPA2:RPA3@default
- CHTF18:PCNA:POLD*:POLE*:POLK:RFC*:RPA1:RPA2|pho:RPA3:XRCC1|pho@default
- CDK7:CyclinH*:MNAT1:RPA1:RPA2|pho:RPA3:TFIIH1*:TFIIH2*:TFIIH3*:TFIIH4*:TFIIH5*:XAB2:XPA|S196_pho:XPB*:XPD*@default
- BLM:FAAP100*:FAAP20*:FAAP24*:FANCA|pho:FANCB:FANCC:FANCE|S376_pho|T346_pho:FANCF:FANCG|S7_pho:FANCL:FANCM:HES1:RPA1:RPA2:RPA3:TOP3A@default
- CDK7:CyclinH*:ERCC1:MNAT1:RPA1:RPA2|pho:RPA3:TFIIH1*:TFIIH2*:TFIIH3*:TFIIH4*:TFIIH5*:XAB2:XPA|S196_pho:XPB*:XPD*:XPF*:XPG*@default
- CDC45:CDC6:CDT1:MCM2:MCM3:MCM4:MCM5:MCM6:MCM7:ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*:POLA*:PRIM*:RPA1:RPA2:RPA3@default
Participates in reactions:
As Reactant or Product:- d_s2743 + d_s834 + EXO1@default
+ RPA1:RPA2:RPA3@default
+ PCNA@default
+ RFC*@Nucleus
→
EXO1:PCNA:RFC*:RPA1:RPA2:RPA3:hMutL*:hMutS*@Nucleus
- RPA1:RPA2:RPA3@default
+ SMARCAL1|pho@default
→
RPA1:RPA2:RPA3:SMARCAL1|pho@default
- CDK7:CyclinH*:MNAT1:TFIIH1*:TFIIH2*:TFIIH3*:TFIIH4*:TFIIH5*:XPB*:XPD*@default
+ RPA1:RPA2|pho:RPA3@default
+ XAB2:XPA|S196_pho@default
→
CDK7:CyclinH*:MNAT1:RPA1:RPA2|pho:RPA3:TFIIH1*:TFIIH2*:TFIIH3*:TFIIH4*:TFIIH5*:XAB2:XPA|S196_pho:XPB*:XPD*@default
- CDK7:CyclinH*:MNAT1:RPA1:RPA2|pho:RPA3:TFIIH1*:TFIIH2*:TFIIH3*:TFIIH4*:TFIIH5*:XAB2:XPA|S196_pho:XPB*:XPD*@default
+ ERCC1@default
+ XPF*@default
+ XPG*@default
→
CDK7:CyclinH*:ERCC1:MNAT1:RPA1:RPA2|pho:RPA3:TFIIH1*:TFIIH2*:TFIIH3*:TFIIH4*:TFIIH5*:XAB2:XPA|S196_pho:XPB*:XPD*:XPF*:XPG*@default
- BRCA1|S988_pho|S1387_pho|S1423_pho|S1497_pho|S1524_pho|active@default
+ BRCA2@default
+ FANCJ*@default
+ RPA1:RPA2:RPA3@default
+ FANCN*@default
+ FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho@default
→
BRCA1:BRCA2:FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho:FANCJ*:FANCN*:RPA1:RPA2:RPA3@default
- BLM:FAAP100*:FAAP20*:FAAP24*:FANCA|pho:FANCB:FANCC:FANCE|S376_pho|T346_pho:FANCF:FANCG|S7_pho:FANCL:FANCM:HES1@default
+ TOP3A@default
+ RPA1:RPA2:RPA3@default
→
BLM:FAAP100*:FAAP20*:FAAP24*:FANCA|pho:FANCB:FANCC:FANCE|S376_pho|T346_pho:FANCF:FANCG|S7_pho:FANCL:FANCM:HES1:RPA1:RPA2:RPA3:TOP3A@default
- POLE*@default
+ POLD*@default
+ RFC*@Nucleus
+ PCNA@default
+ CHTF18@default
+ POLK@default
+ XRCC1|pho@default
+ RPA1:RPA2|pho:RPA3@default
→
CHTF18:PCNA:POLD*:POLE*:POLK:RFC*:RPA1:RPA2|pho:RPA3:XRCC1|pho@default
- RAD52@default
+ RPA1:RPA2|pho:RPA3@default
→
RAD52:RPA1:RPA2|pho:RPA3@default
- BRCA1:BRCA2:FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho:FANCJ*:FANCN*:RPA1:RPA2:RPA3@default
→
BRCA1:BRCA2:FANCD2|pho:FANCI|pho:FANCJ*:FANCN*:RPA1:RPA2:RPA3@default
- ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*@default
+ MCM2:MCM3:MCM4:MCM5:MCM6:MCM7@default
+ CDT1@default
+ CDC6@default
+ CDC45@default
+ POLA*@default
+ PRIM*@default
+ RPA1@Nucleus
+ RPA2@Nucleus
+ RPA3@Nucleus
→
CDC45:CDC6:CDT1:MCM2:MCM3:MCM4:MCM5:MCM6:MCM7:ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*:POLA*:PRIM*:RPA1:RPA2:RPA3@default
- RPA1@default
+ RPA2|pho@default
+ RPA3@default
→
RPA1:RPA2|pho:RPA3@default
- POLD*@default
+ RPA1:RPA2|pho:RPA3@default
→
POLD*:RPA1:RPA2|pho:RPA3@default
- ATRIP:ATR|pho@default
+ CLSPN|pho@default
+ RPA1:RPA2:RPA3@default
→
ATRIP:ATR|pho:CLSPN|pho:RPA1:RPA2:RPA3@default
- RPA1@default
+ RPA2@default
+ RPA3@default
→
RPA1:RPA2:RPA3@default
- ATRIP:ATR|pho:CLSPN|pho:RPA1:RPA2:RPA3@default
+ TIPIN@default
+ TIM1*@default
+ CHEK1|pho|active@default
→
ATRIP:ATR|pho:CHEK1|pho:CLSPN|pho:RPA1:RPA2:RPA3:TIM1*:TIPIN@default
As Catalyser:- S phase@default
→
G2 phase@default
- gGG-NER_DNA_st2*@Nucleus
→
gTC-NER_GG-NER_DNA_st3*@Nucleus
- gHR_DNA_st2*@Nucleus
→
gHR_DNA_st3*@Nucleus
- gHR_DNA_st3*@Nucleus
→
gHR_DNA_st4*@Nucleus
- gTC-NER_DNA_st2*@Nucleus
→
gTC-NER_GG-NER_DNA_st3*@Nucleus
- gFanconi_DNA_st2*@Nucleus
→
gFanconi_DNA_st3*@Nucleus
- gFanconi_DNA_st4*@Nucleus
→
gFanconi_DNA_st5*@Nucleus
- gFanconi_DNA_st5*@Nucleus
→
gTC-NER_GG-NER_DNA_st4*@Nucleus
- gFanconi_DNA_st4*@Nucleus
→
gHR_DNA_st2*@Nucleus
- gSSA_DNA_st2*@Nucleus
→
gSSA_DNA_st3*@Nucleus
- gTC-NER_GG-NER_DNA_st3*@Nucleus
→
gTC-NER_GG-NER_DNA_st4*@Nucleus
+ Modified 24-32 nucleotides fragment@default
- gTC-NER_GG-NER_DNA_st4*@Nucleus
+ dNTPs@Nucleus
→
gTC-NER_GG-NER_DNA_st5*@Nucleus
- gMMR_DNA_st2*@Nucleus
→
gMMR_DNA_st3*@Nucleus
- gMMR_DNA_st3*@Nucleus
→
gMMR_DNA_st4*@Nucleus
- TOPBP1@default
+ ATRIP:ATR|pho@default
+ CLSPN|pho@default
+ RAD17|pho@default
→
ATRIP:ATR|pho:CLSPN|pho:RAD17|pho:TOPBP1@default
- ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*@default
+ MCM2:MCM3:MCM4:MCM5:MCM6:MCM7@default
+ CDT1@default
+ CDC6@default
+ CDC45@default
+ POLA*@default
+ PRIM*@default
+ RPA1@Nucleus
+ RPA2@Nucleus
+ RPA3@Nucleus
→
CDC45:CDC6:CDT1:MCM2:MCM3:MCM4:MCM5:MCM6:MCM7:ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*:POLA*:PRIM*:RPA1:RPA2:RPA3@default
- No DNA replicarion@default
→
DNA replicarion@default
- RAD1@default
+ RAD9*|pho@default
+ HUS1@default
→
HUS1:RAD1:RAD9*|pho@default
- HUS1:RAD1:RAD9*|pho@default
+ RAD17@default
+ RFC*@Nucleus
→
HUS1:RAD1:RAD17:RAD9*:RFC*@default