Protein eIF4G
To date, no functional effect of these three phosphorylation sites has
been reported. Since rapamycin prevents the serum-induced phosphorylation of these 3 residues, we decided to illustrate the phosphorylated form of eIF4G.
eIF4G is also phosphorylated in vitro by protein kinase C, multifunctional S6 kinase, and the p21-activated protein kinase Pak2/gamma-PAK.
PMID:2914929
PMID:2355012
PMID:2002015
eIF4G|​S1108_pho|​S1148_pho|​S1192_pho@Cell membrane
To date, no functional effect of these three phosphorylation sites has
been reported. Since rapamycin prevents the serum-induced phosphorylation of these residues, we decided to illustrate the phosphorylated form of eIF4G in the translation initiation complex.

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Modifications:
In compartment: Cell membrane

1. eIF4G@Cell membrane
2. eIF4G|​S1108_pho|​S1148_pho|​S1192_pho@Cell membrane

Participates in complexes:
In compartment: Cell membrane

1. Pak2:​eIF4G@Cell membrane
2. Pak2:​eIF4G|​S896_pho@Cell membrane
3. eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
4. eIF4A:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
5. Mnk1/2:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
6. Mnk1/2:​eIF4E|​S209_pho:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
7. eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
8. eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
9. PABP:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
10. PABP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane

Participates in reactions:
As Reactant or Product:

1. eIF4E:​m7GTP:​mRNA@Cell membrane + eIF4G|​S1108_pho|​S1148_pho|​S1192_pho@Cell membrane → eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
2. eIF4G@Cell membrane → eIF4G|​S1108_pho|​S1148_pho|​S1192_pho@Cell membrane
3. eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane + eIF4A@Cell membrane → eIF4A:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
4. eIF4A:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane + eIF4B|​S422_pho@Cell membrane → eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
5. eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane + eIF3@Cell membrane → eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
6. PABP@Cell membrane + eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane → PABP:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
7. Mnk1/2:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane → Mnk1/2:​eIF4E|​S209_pho:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
8. eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane + Mnk1/2@Cell membrane → Mnk1/2:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
9. Raptor|​S722_pho|​S719_pho|​S721_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → PABP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
10. PABP:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane + GDP:​eIF2_alpha:​eIF2_beta:​eIF2_gamma:​eIF3:​rpS6/40S subunit|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cell membrane → 5'cap-eIF4F-eIF4B-eIF3-PABP:​eIF2-GTP_Met-tRNAi_40S@Cell membrane
11. PABP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 5'cap-eIF4F-eIF4B-eIF3-PABP:​eIF2-GTP_Met-tRNAi_40S@Cell membrane
12. Pak2:​eIF4G@Cell membrane → Pak2:​eIF4G|​S896_pho@Cell membrane
13. Pak2@Cell membrane + eIF4G@Cell membrane → Pak2:​eIF4G@Cell membrane

As Catalyser:

1. eIF4E@Cell membrane + m7GTP:​mRNA@Cell membrane → eIF4E:​m7GTP:​mRNA@Cell membrane
2. eIF4E:​m7GTP:​mRNA@Cell membrane + eIF4G|​S1108_pho|​S1148_pho|​S1192_pho@Cell membrane → eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
3. Mnk1/2:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane → Mnk1/2:​eIF4E|​S209_pho:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
4. Pak2:​eIF4G@Cell membrane → Pak2:​eIF4G|​S896_pho@Cell membrane