Protein TNF_alpha

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Modifications:
In compartment: default

1. TNF_alpha@default

Participates in complexes:
In compartment: Cell membrane

1. TNFR:​TNF_alpha@Cell membrane
2. TNFR|​hm3:​TNF_alpha@Cell membrane
3. TNFR|​hm3:​TNF_alpha:​TRADD@Cell membrane
4. FADD:​TNFR:​TNFR|​hm2:​TNF_alpha@Cell membrane
5. RIP1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5@Cell membrane
6. RIP1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
7. RIP1|​K377_ubi:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
8. MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
9. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
10. IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane

Participates in reactions:
As Reactant or Product:

1. TNF_alpha@default + TNFR@Cell membrane → TNFR:​TNF_alpha@Cell membrane
2. TNFR:​TNF_alpha@Cell membrane → TNFR|​hm3:​TNF_alpha@Cell membrane
3. TRADD@Cell membrane + TNFR|​hm3:​TNF_alpha@Cell membrane → TNFR|​hm3:​TNF_alpha:​TRADD@Cell membrane
4. TRAF2/5@Cell membrane + TNFR|​hm3:​TNF_alpha:​TRADD@Cell membrane → RIP1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5@Cell membrane
5. RIP1@Cell membrane + TNFR|​hm3:​TNF_alpha:​TRADD@Cell membrane → RIP1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5@Cell membrane
6. RIP1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → RIP1|​K377_ubi:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
7. Ubc13:​Uev1A@Cell membrane + RIP1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5@Cell membrane → RIP1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
8. TAK1@Cell membrane + RIP1|​K377_ubi:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
9. MEKK3@Cell membrane + RIP1|​K377_ubi:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
10. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO@Cell membrane + MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
11. FADD:​TNFR:​TNFR|​hm2:​TNF_alpha@Cell membrane → Apoptosis@Cell membrane
12. TNFR|​hm3:​TNF_alpha@Cell membrane + FADD@Cell membrane → FADD:​TNFR:​TNFR|​hm2:​TNF_alpha@Cell membrane
13. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
14. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
15. IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_beta|​pho|​active@Cell membrane
16. IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_alpha|​pho|​active@Cell membrane

As Catalyser:

1. RIP1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → RIP1|​K377_ubi:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
2. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
3. IKK_alpha:​IKK_beta:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane → IKK_alpha|​pho:​IKK_beta|​pho:​IKK_gamma_/NEMO:​MEKK3:​RIP1|​K377_ubi:​TAK1:​TNFR|​hm3:​TNF_alpha:​TRADD:​TRAF2/5:​Ubc13:​Uev1A@Cell membrane
4. I_kappa_B_alpha_:​p50 (NF_kappa_B):​p65(NF_kappa_B)@Cell membrane → I_kappa_B_alpha_|​S32_pho|​S36_pho:​p50 (NF_kappa_B):​p65(NF_kappa_B)@Cell membrane