Protein MyD88

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Modifications:
In compartment: cytosol

1. MyD88@cytosol
2. MyD88|​hm2@cytosol
3. MyD88|​Y257_pho|​hm2@cytosol

Participates in complexes:
In compartment: cytosol

1. MyD88:​MyD88s@cytosol
2. MyD88|​hm2:​TIR domain@cytosol
3. MyD88|​hm2:​ST2L:​TIRAP@cytosol
4. IRAK4:​MyD88|​hm2:​TIR domain@cytosol
5. MyD88|​hm2:​TIR domain:​TIRAP@cytosol
6. IRF7:​MyD88|​hm2:​TRAF6|​hm2@cytosol
7. IRF7:​MyD88|​hm2:​TRAF6|​ubi|​hm2@cytosol
8. IRAK1:​IRAK4:​MyD88|​hm2:​TIR domain@cytosol
9. IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP@cytosol
10. IRAK1|​T209_pho:​IRAK4:​MyD88|​hm2:​TIR domain@cytosol
11. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain@cytosol
12. IRAK2:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP@cytosol
13. IRAK1:​IRAK4:​MyD88|​hm2:​TIR domain:​TOLLIP@cytosol
14. IRAK1|​T209_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TOLLIP@cytosol
15. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP@cytosol
16. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TOLLIP@cytosol
17. IRAK1:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP:​TOLLIP@cytosol
18. IRAK1c:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP:​TOLLIP@cytosol
19. IRAK1c:​IRAK4:​MyD88|​hm2:​TIR domain:​TOLLIP:​TRAF6|​hm2@cytosol
20. IRAK1|​T209_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP:​TOLLIP@cytosol
21. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP:​TOLLIP@cytosol
22. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIFA:​TIR domain:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
23. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIFA:​TIR domain:​TIRAP:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol

Participates in reactions:
As Reactant or Product:

1. IRAK4:​MyD88|​hm2:​TIR domain@cytosol + IRAK1@cytosol → IRAK1:​IRAK4:​MyD88|​hm2:​TIR domain@cytosol
2. IRAK1:​IRAK4:​MyD88|​hm2:​TIR domain@cytosol → IRAK1|​T209_pho:​IRAK4:​MyD88|​hm2:​TIR domain@cytosol
3. IRAK1|​T209_pho:​IRAK4:​MyD88|​hm2:​TIR domain@cytosol → IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain@cytosol
4. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain@cytosol + TRAF6|​hm2@cytosol + TIFA@cytosol + Ubc13@cytosol + Uev1A@cytosol → IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIFA:​TIR domain:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
5. IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP@cytosol + IRAK1:​TOLLIP@cytosol → IRAK1:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP:​TOLLIP@cytosol
6. IRAK1:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP:​TOLLIP@cytosol → IRAK1|​T209_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP:​TOLLIP@cytosol
7. IRAK1|​T209_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP:​TOLLIP@cytosol → IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP:​TOLLIP@cytosol
8. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP:​TOLLIP@cytosol → IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP@cytosol + TOLLIP|​pho@cytosol
9. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIFA:​TIR domain:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol → IRAK4:​MyD88|​hm2:​TIR domain@cytosol + IRAK1|​T209_pho|​T387_pho:​TIFA:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
10. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIFA:​TIR domain:​TIRAP:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol → IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP@cytosol + IRAK1|​T209_pho|​T387_pho:​TIFA:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
11. MyD88|​hm2@cytosol → MyD88|​Y257_pho|​hm2@cytosol
12. MyD88@cytosol → MyD88|​hm2@cytosol
13. MyD88|​hm2@cytosol + TIR domain:​TIRAP@cytosol → MyD88|​hm2:​TIR domain:​TIRAP@cytosol
14. TIR domain@cytosol + MyD88|​hm2@cytosol → MyD88|​hm2:​TIR domain@cytosol
15. IRAK4@cytosol + MyD88|​hm2:​TIR domain@cytosol → IRAK4:​MyD88|​hm2:​TIR domain@cytosol
16. MyD88@cytosol + MyD88s@cytosol → MyD88:​MyD88s@cytosol
17. MyD88|​hm2@cytosol + ST2L@cytosol + TIRAP@cytosol → MyD88|​hm2:​ST2L:​TIRAP@cytosol
18. IRF7:​MyD88|​hm2:​TRAF6|​hm2@cytosol → IRF7:​MyD88|​hm2:​TRAF6|​ubi|​hm2@cytosol
19. IRF7:​MyD88|​hm2:​TRAF6|​ubi|​hm2@cytosol → IRF7|​S485_pho|​active@cytosol + MyD88|​hm2@cytosol + TRAF6|​ubi|​hm2@cytosol
20. IRAK2@cytosol + IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP@cytosol → IRAK2:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP@cytosol
21. MyD88|​hm2:​TIR domain:​TIRAP@cytosol + IRAK4@cytosol → IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP@cytosol
22. MyD88|​hm2@cytosol + TRAF6|​hm2@cytosol + IRF7@cytosol → IRF7:​MyD88|​hm2:​TRAF6|​hm2@cytosol
23. IRAK1c:​TOLLIP@cytosol + TRAF6|​hm2@cytosol + IRAK4:​MyD88|​hm2:​TIR domain@cytosol → IRAK1c:​IRAK4:​MyD88|​hm2:​TIR domain:​TOLLIP:​TRAF6|​hm2@cytosol
24. TRAF6|​hm2@cytosol + IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP@cytosol + Ubc13@cytosol + Uev1A@cytosol + TIFA@cytosol → IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIFA:​TIR domain:​TIRAP:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
25. IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP@cytosol + IRAK1c:​TOLLIP@cytosol → IRAK1c:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP:​TOLLIP@cytosol
26. IRAK4:​MyD88|​hm2:​TIR domain@cytosol + IRAK1:​TOLLIP@cytosol → IRAK1:​IRAK4:​MyD88|​hm2:​TIR domain:​TOLLIP@cytosol
27. IRAK1:​IRAK4:​MyD88|​hm2:​TIR domain:​TOLLIP@cytosol → IRAK1|​T209_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TOLLIP@cytosol
28. IRAK1|​T209_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TOLLIP@cytosol → IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TOLLIP@cytosol
29. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TOLLIP@cytosol → TOLLIP|​pho@cytosol + IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain@cytosol

As Catalyser:

1. IRAK1:​IRAK4:​MyD88|​hm2:​TIR domain@cytosol → IRAK1|​T209_pho:​IRAK4:​MyD88|​hm2:​TIR domain@cytosol
2. IRAK1|​T209_pho:​IRAK4:​MyD88|​hm2:​TIR domain@cytosol → IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain@cytosol
3. IRAK1:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP:​TOLLIP@cytosol → IRAK1|​T209_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP:​TOLLIP@cytosol
4. IRAK1|​T209_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP:​TOLLIP@cytosol → IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP:​TOLLIP@cytosol
5. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP:​TOLLIP@cytosol → IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP@cytosol + TOLLIP|​pho@cytosol
6. FADD@cytosol + pro-caspase8@cytosol → FADD:​pro-caspase8@cytosol
7. IRF7:​MyD88|​hm2:​TRAF6|​ubi|​hm2@cytosol → IRF7|​S485_pho|​active@cytosol + MyD88|​hm2@cytosol + TRAF6|​ubi|​hm2@cytosol
8. PI3K (p110):​PI3K (p85)@cytosol → PI3K (p110):​PI3K(p85)*@cytosol
9. TAB1:​TAB2_br_TAB3|​pho|​ubi:​TAK1|​pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → TAB1:​TAB2_br_TAB3|​pho|​ubi:​TAK1|​pho|​T187_pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
10. IRAK1:​IRAK4:​MyD88|​hm2:​TIR domain:​TOLLIP@cytosol → IRAK1|​T209_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TOLLIP@cytosol
11. IRAK1|​T209_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TOLLIP@cytosol → IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TOLLIP@cytosol
12. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TOLLIP@cytosol → TOLLIP|​pho@cytosol + IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain@cytosol