IKK_alpha

Protein IKK_alpha_*

Identifiers
HUGO:CHUK

Maps_Modules
MACROPHAGE
MDSC
DENDRITIC_CELL
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
CASCADE:STING
CASCADE:TLR2_4

References
PMID:17485448
TNIP3 (ABIN3‭) ‬inhibits IKK complex trough direct binding to IKBKG.
It results in inhibition of‭ ‬FNKBIA phosphorylation and
proteasomal degradation and prevents activation
of downstream‭ ‬NFkB‭ ‬signaling‭ ‬downstream of IL10.
PMID:17237376, PMID:21807870
Alternative pathways involeved IKKa activation by NIK. This signaling is important for DC maturation and T-cell activation (). NIK signaling is required in DCs to deliver co-stimulatory signals to CD4+ T cells
PMID:23086447
Alternative NFkB pathway induces via phosphorylation of IκB-specific kinase α (IKK-α) the cleavage of p100-RelB to p52-RelB, which then translocates as heterodimer into the nucleus.
Both complete p100 degradation and p100 processing to p52 may occur in Dcs and expression of IKKa, the kinase determining the activity of noncanonical NF-κB pathway, gradually increased during DC differentiation with concomitant p100 processing to p52
PMID:2649237
In macrophages RELB /p52 pathway is associated with M1 polarization
PMID:23422957
IKKa could regulate IRF3 activity and IRF3-dependent IFNβ and IL-12 production by DC. TAK1 (MAP3K7)-mediated IKKα/β activation is required for IRF3-dependent IFNβ expression in DC. At the same time IKKα regulates IRF3-mediated transcription downstream of IKKɛ/TBK1mediated IRF3 phosphorylation. IKKa increases the association of IRF3 with the transcriptional co-activator CBP. The increased recruitment of CBP after overexpression of IKKα was also associated with increased transcription of endogenous IFNβ mRNA.
PMID:17254973
NfkB heterodiners could be also bloked by p52 precursor, protein p100. Dissosiation of p100 from the comprex reactivate NF-kB signaling
NIK and IKK1 regulates the degradation of nfkb2 p100 to effect NF-κB/RelA activation.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol

IKK_alpha_*|hm2@INNATE_IMMUNE_CELL_Cytosol
IKK_alpha_*|pho|hm2|active@INNATE_IMMUNE_CELL_Cytosol

Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: