Protein IL6R map

Identifiers
HUGO:IL6R

Maps_Modules
 MACROPHAGE  map
MODULE:INPUT_INHIBITORS
MODULE:IMMUNE_SUPPRESSION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
CASCADE:IL6

References
PMID:12754507, PMID:24418198
SOCS3 binds with high affinity to the phosphorylated Tyr759 (Y759)
Of gp130 to suppress IL-6 signaling.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL6R@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IL6R:​SOCS3:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL6R:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map
  2. IL6:​IL6R:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map
  3. IL6:​IL6R:​JAK1|​pho:​JAK2|​pho:​TYK2|​pho:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL6:​IL6R:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map → map IL6:​IL6R:​JAK1|​pho:​JAK2|​pho:​TYK2|​pho:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map
  2. SOCS3@INNATE_IMMUNE_CELL_Cytosol map + IL6R:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map → map IL6R:​SOCS3:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Cytosol map
  3. IL6R:​SOCS3:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Cytosol map → map degraded
  4. IL6@default map + IL6R:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map → map IL6:​IL6R:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map
  5. gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map + IL6R@INNATE_IMMUNE_CELL_Membrane map → map IL6R:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. TNF@INNATE_IMMUNE_CELL_Cytosol map → map TNF@default map
  2. JAK1@INNATE_IMMUNE_CELL_Cytosol map → map JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. TYK2@INNATE_IMMUNE_CELL_Cytosol map → map TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. JAK2@INNATE_IMMUNE_CELL_Cytosol map → map JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. STAT3@INNATE_IMMUNE_CELL_Cytosol map → map STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map