Protein CREB1 map

Identifiers
HUGO:CREB1

Maps_Modules
 MACROPHAGE  map
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
CASCADE:TLR2_4
CASCADE:IFNG

References
PMID:16713974
RNAi-mediated knockdown of CREB, Fos, and Jun expression resulted in diminished TLR2-induced IL-10 production.
TLR activation of CREB by phosphorylation of serine-133 is dependent on p38.
PMID:16713974, PMID:11579131
INFG pathway inhibits activation (phosphorylation) of ERK, JNK, p38 kinases and PI3K pathway induced by TLR. Inhibition of AKT pathway by IFNG resulted in activation of GSK3. GSK3 inhibits downstream AP-1 and CREB1 signaling and downregulates IL10 expression induced by TLR.IFNG inhibits CREB activation via p38 induced by TLR signaling

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CREB1@INNATE_IMMUNE_CELL_Cytosol map
  2. CREB1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CBP*:​CREB1|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. CREB1@INNATE_IMMUNE_CELL_Cytosol map → map CREB1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. CREB1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + CBP*@INNATE_IMMUNE_CELL_Cytosol map → map CBP*:​CREB1|​pho@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. CBP*@INNATE_IMMUNE_CELL_Cytosol map + RELA@INNATE_IMMUNE_CELL_Cytosol map → map CBP*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  2. gIL10@INNATE_IMMUNE_CELL_Cytosol map → map rIL10@INNATE_IMMUNE_CELL_Cytosol map
  3. gPTGS2@INNATE_IMMUNE_CELL_Cytosol map → map rPTGS2@INNATE_IMMUNE_CELL_Cytosol map