Protein CBP* map

Identifiers
HUGO:CREBBP

Maps_Modules
 MACROPHAGE  map
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

References
PMID:19879327
STAT1 is acetylated by CBP at the lysine residues K410 and K413.
PMID:16007092
GSK3B induces RELA (p65) interaction with CBP and activates downstream NF-kB signaling end expression of proinflammatory cytokines.
PMID:12417340
IRF-8/ICSBP and IRF-1 cooperatively stimulate mouse IL-12 p40 promoter activity in macrophages.
IRF-1 can be acetylated by p300. p300 is recruited to the IL-12p40 promoter depending on both ICSBP and IRF-1
and acts as coactivator in macrophages.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CBP*@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CBP*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  2. CBP*:​CREB1|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. CBP*@INNATE_IMMUNE_CELL_Cytosol map + RELA@INNATE_IMMUNE_CELL_Cytosol map → map CBP*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  2. CREB1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + CBP*@INNATE_IMMUNE_CELL_Cytosol map → map CBP*:​CREB1|​pho@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. NFkB*@INNATE_IMMUNE_CELL_Cytosol map → map NFkB*@INNATE_IMMUNE_CELL_Cytosol map
  2. CBP*@INNATE_IMMUNE_CELL_Cytosol map + RELA@INNATE_IMMUNE_CELL_Cytosol map → map CBP*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  3. STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​ace@INNATE_IMMUNE_CELL_Cytosol map
  4. IRF1@INNATE_IMMUNE_CELL_Cytosol map → map IRF1|​ace@INNATE_IMMUNE_CELL_Cytosol map