Protein RELA map

Identifiers
HUGO:RELA

Maps_Modules
 MACROPHAGE  map
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
CASCADE:IL2
CASCADE:CSF2
CASCADE:TNF
CASCADE:IFNG

References
PMID:19171876
NFkB signaling via RELA:p50 heterodimer provides
expression of proinflamatory cytokines and realisation
of M1 phenotype of macrophages.
PMID:17550372, PMID:9743347
IL13 inhibits NFκB activation via inhibition of p65 nuclear migration in inflammatory marophages

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. RELA@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CBP*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  2. NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  3. IkB*:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  4. NFKB1_p50*:​RELA:​p100@INNATE_IMMUNE_CELL_Cytosol map
  5. IkB*|​pho:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map → map NFkB*@INNATE_IMMUNE_CELL_Cytosol map
  2. rRELA@INNATE_IMMUNE_CELL_Cytosol map → map RELA@INNATE_IMMUNE_CELL_Cytosol map
  3. CBP*@INNATE_IMMUNE_CELL_Cytosol map + RELA@INNATE_IMMUNE_CELL_Cytosol map → map CBP*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  4. IkB*:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map → map IkB*|​pho:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  5. IkB*|​pho:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map + IkB*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  6. NFKB1_p50*:​RELA:​p100@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map + p100@INNATE_IMMUNE_CELL_Cytosol map
  7. NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map + RELA@INNATE_IMMUNE_CELL_Cytosol map + IkB*@INNATE_IMMUNE_CELL_Cytosol map → map IkB*:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. NFkB*@INNATE_IMMUNE_CELL_Cytosol map → map NFkB*@INNATE_IMMUNE_CELL_Cytosol map