Protein SOCS1 map

Identifiers
HUGO:SOCS1

Maps_Modules
 MACROPHAGE  map
 DENDRITIC_CELL  map
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
CASCADE:IL13
CASCADE:IFNG
CASCADE:IL4

References
SOCS-1 decreases IFNG signaling via inhiviting the catalytic activity of JAKs.
PMID:12811837
SOCS-1 overexpression resulted in a nearly complete loss of IFNG responsiveness in macrophages.
PMID:10485906
SOCS1 inhibits STAT6 activation downstream of IFNG and downregulates IL4 signaling pathway.
PMID:12193701
INFG upregulates TNFR1 and RIPK1 expression, probably via JAK/STAT1 pathway
because this expression is inhibited in presense of SOCS1.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. SOCS1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rSOCS1@INNATE_IMMUNE_CELL_Cytosol map → map SOCS1@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. IFNG|​hm2@default map + IFNGR1:​IFNGR2@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map → map IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@INNATE_IMMUNE_CELL_Membrane map
    2. STAT6@INNATE_IMMUNE_CELL_Cytosol map → map STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
    3. gTNFR1*@INNATE_IMMUNE_CELL_Cytosol map → map rTNFR1*@INNATE_IMMUNE_CELL_Cytosol map
    4. gRIPK1@INNATE_IMMUNE_CELL_Cytosol map → map rRIPK1@INNATE_IMMUNE_CELL_Cytosol map
    5. STAT6@INNATE_IMMUNE_CELL_Cytosol map → map STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map