Protein STAT6 map

Identifiers
HUGO:STAT6

Maps_Modules
 MACROPHAGE  map
 MDSC  map
 DENDRITIC_CELL  map
MODULE:INPUT_INHIBITORS
MODULE:IMMUNE_SUPPRESSION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
CASCADE:IL4
CASCADE:IL13
CASCADE:CSF2
CASCADE:IFNG

References
PMID:12223527
Stat proteins 1 alpha, 3, 5A, 5B, and 6 are phosphorylated in response to IL-13.
IL-4, in contrast to IL-13, induced very low levels of phosphorylation of Stats 1 and 5 and a more robust phosphorylation of Stat3 and Stat6.
PMID:23124025
Jak1 is required for Stat6 (TYR641) activation in monocytes stimulated with IL-4
PMID:14610620
When the type I
or type II IL-4R is dimerized, JAKs associated with
the receptor components phosphorylate the second,
third, or fourth tyrosine residues of the IL-4Ra cytoplasmic domain [50]. This phosphorylation recruits
Stat6, which is then also phosphorylated. PhosphoStat6 molecules dimerize and migrate to the nucleus to
bind to certain promoters.
PMID:10485906
SOCS1 inhibits STAT6 activation downstream of IFNG and downregulates IL4 signaling pathway.
PMID:15634881
STAT6-deficient mice produce M1 macrophages.
STAT6 deficiency prevents signaling through the type 2 IL-4Ralpha, thereby blocking the production of arginase and promoting the synthesis of NO in MDSC.
PMID:12244147
GM-CSF can activate STAT6 in murine BM-DC
PMID:12244147, PMID:24204259
Additionally IL4 via IL-4R type I JAK3 and STAT6 (but not IL13) upregulates production of IL12p70

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. STAT6@INNATE_IMMUNE_CELL_Cytosol map
  2. STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PPARG:​STAT6|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + PPARG@INNATE_IMMUNE_CELL_Cytosol map → map PPARG:​STAT6|​pho@INNATE_IMMUNE_CELL_Cytosol map
  2. STAT6@INNATE_IMMUNE_CELL_Cytosol map → map STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. rSTAT6@INNATE_IMMUNE_CELL_Cytosol map → map STAT6@INNATE_IMMUNE_CELL_Cytosol map
  4. STAT6@INNATE_IMMUNE_CELL_Cytosol map → map STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. gMAOA@INNATE_IMMUNE_CELL_Cytosol map → map rMAOA@INNATE_IMMUNE_CELL_Cytosol map
  2. gPPARG@INNATE_IMMUNE_CELL_Cytosol map → map rPPARG@INNATE_IMMUNE_CELL_Cytosol map
  3. gCD36@INNATE_IMMUNE_CELL_Cytosol map → map rCD36@INNATE_IMMUNE_CELL_Cytosol map
  4. gDUSP1@INNATE_IMMUNE_CELL_Cytosol map → map rDUSP1@INNATE_IMMUNE_CELL_Cytosol map
  5. gKDM6B@INNATE_IMMUNE_CELL_Cytosol map → map rKDM6B@INNATE_IMMUNE_CELL_Cytosol map
  6. IL12*@INNATE_IMMUNE_CELL_Cytosol map → map IL12*@default map
  7. gIL13RA2@INNATE_IMMUNE_CELL_Cytosol map → map rIL13RA2@INNATE_IMMUNE_CELL_Cytosol map
  8. gKLF4@INNATE_IMMUNE_CELL_Cytosol map → map rKLF4@INNATE_IMMUNE_CELL_Cytosol map
  9. gMHC class II*@INNATE_IMMUNE_CELL_Cytosol map → map rMHC class II*@INNATE_IMMUNE_CELL_Cytosol map
  10. gHIF2A*@INNATE_IMMUNE_CELL_Cytosol map → map rHIF2A*@INNATE_IMMUNE_CELL_Cytosol map