Protein PRKCQ map

Identifiers
HUGO:PRKCQ

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

References
 NATURAL_KILLER  map
CASCADE:IFNAB
PMID:25960930
IFNα induces PKC-θ auto-phosphorylation in NK cells via P3K and PLC pathways and improves the degranulation via PKC-θ signaling
Reduced IFNα-induced STAT-1 phosphorylation in Ser727 and CXCL10 secretion in NK cells derived from PKC-θ−/− mice
PMID:19201850
Protein kinase C-theta is required for NK cell activation and in vivo control of tumor progression.
PRKCQ upregulates granzyme A and B expression in NK cells recruited to the tumor environment.
PRKCQ could be activated downstream of IL15 and TLR3 signaling.
PMID:16606694
WIPF1 forms complex with WASP. Protein kinase C-theta mediates phosphorylation of WIPF1 downstream of NK activation. Inhibitory signaling from KIR2DL1 receptor.
PMID:18784374; PMID:23077238, PMID:17548359
PKC-theta requires DAG for activation. DAG is generated by PLCG through enzymatic cleavage of PIP2.
PMID:18784374
PKC-theta–mediated signals activate AP-1 and NFAT1.
The capacity of NFAT to bind DNA was reduced in PKC-theta–deficient NK cells.
There is a significant decrease in AP-1 activation in PKC-theta–deficient NK cells.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PRKCQ@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. DAG:​PRKCQ@INNATE_IMMUNE_CELL_Cytosol map
  2. DAG:​PRKCQ|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. DAG@INNATE_IMMUNE_CELL_Cytosol map + PRKCQ@INNATE_IMMUNE_CELL_Cytosol map → map DAG:​PRKCQ@INNATE_IMMUNE_CELL_Cytosol map
  2. DAG:​PRKCQ@INNATE_IMMUNE_CELL_Cytosol map → map DAG:​PRKCQ|​pho@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. gIRF9@INNATE_IMMUNE_CELL_Cytosol map → map rIRF9@INNATE_IMMUNE_CELL_Cytosol map
  2. NFAT*|​pho@INNATE_IMMUNE_CELL_Cytosol map → map NFAT*@INNATE_IMMUNE_CELL_Cytosol map
  3. STAT1@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  4. WASP*|​pho:​WIPF1@INNATE_IMMUNE_CELL_Cytosol map → map WASP*|​pho:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. rGZMB@INNATE_IMMUNE_CELL_Cytosol map → map GZMB@SECRETORY_GRANULE map
  6. rGZMA@INNATE_IMMUNE_CELL_Cytosol map → map GZMA@SECRETORY_GRANULE map