Protein STING* map

Identifiers
HUGO:TMEM173

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:TUMOR_RECOGNTITON MODULE:DANGER_SIGNAL_PATHWAYS

References
 DENDRITIC_CELL  map
CASCADE:STING
PMID:24766893
Cytosolic DNA induces type I IFNs through the endoplasmic reticulum membrane protein STING, which subsequently activates the transcription factors NF-κB and IRF3 through the kinases IKK and TBK1, respectively
PMID: 23986532
STING ablation abolished hallmark TGF-β and IL-10 regulatory cytokine induction (mRNA)by apoptotic cells, and proinflammatory IL-6 mRNA was expressed instead in DCs

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. STING*@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. STING*:​cGAMP@INNATE_IMMUNE_CELL_Cytosol map
  2. STING*:​TBK1:​cGAMP@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. STING*@INNATE_IMMUNE_CELL_Cytosol map + cGAMP@INNATE_IMMUNE_CELL_Cytosol map → map STING*:​cGAMP@INNATE_IMMUNE_CELL_Cytosol map
  2. STING*:​cGAMP@INNATE_IMMUNE_CELL_Cytosol map + TBK1@INNATE_IMMUNE_CELL_Cytosol map → map STING*:​TBK1:​cGAMP@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. gTGFB1@INNATE_IMMUNE_CELL_Cytosol map → map rTGFB1@INNATE_IMMUNE_CELL_Cytosol map
  2. gIL10@INNATE_IMMUNE_CELL_Cytosol map → map rIL10@INNATE_IMMUNE_CELL_Cytosol map
  3. gIL6@INNATE_IMMUNE_CELL_Cytosol map → map rIL6@INNATE_IMMUNE_CELL_Cytosol map
  4. IRF3@INNATE_IMMUNE_CELL_Cytosol map → map IRF3|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol map