Protein IRF4 map

Identifiers
HUGO:IRF4

Maps_Modules
 MACROPHAGE  map
CASCADE:IL4
MODULE:IMMUNOSUPPPRESSIVE_CORE_PATHWAYS
MODULE:MIRNA_TF_IMMUNOSUPPRESSIVE

References
PMID:20580461
IRF4 regulates expression of some IL4-dependent genes in macrophages. IRF4 upregulates expression of CIITA, CYP1B1, CCL24, MPP6, and downregulate expression IL1RN.
PMID:16243976
IRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IRF4@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rIRF4@INNATE_IMMUNE_CELL_Cytosol map → map IRF4@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. gTNF@INNATE_IMMUNE_CELL_Cytosol map → map rTNF@INNATE_IMMUNE_CELL_Cytosol map
    2. gMPP6@INNATE_IMMUNE_CELL_Cytosol map → map rMPP6@INNATE_IMMUNE_CELL_Cytosol map
    3. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol map → map rIL12p40*@INNATE_IMMUNE_CELL_Cytosol map
    4. gIL6@INNATE_IMMUNE_CELL_Cytosol map → map rIL6@INNATE_IMMUNE_CELL_Cytosol map
    5. gCCL24@INNATE_IMMUNE_CELL_Cytosol map → map rCCL24@INNATE_IMMUNE_CELL_Cytosol map
    6. gIL1RN@INNATE_IMMUNE_CELL_Cytosol map → map rIL1RN@INNATE_IMMUNE_CELL_Cytosol map
    7. gCIITA@INNATE_IMMUNE_CELL_Cytosol map → map rCIITA@INNATE_IMMUNE_CELL_Cytosol map
    8. IFNGR1@INNATE_IMMUNE_CELL_Membrane map + IFNGR2@INNATE_IMMUNE_CELL_Membrane map → map IFNGR1:​IFNGR2@INNATE_IMMUNE_CELL_Membrane map
    9. JNK*@INNATE_IMMUNE_CELL_Cytosol map → map JNK*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map