Complex IKBKG:IKK_alpha_*:IKK_beta_*:TNIP3 map
Complex composition:

  1. IKK_alpha_* map
  2. IKK_beta_* map
  3. IKBKG map
  4. TNIP3 map

IKBKG:​IKK_alpha_*:​IKK_beta_*:​TNIP3@INNATE_IMMUNE_CELL_Cytosol

Identifiers
NAME:IKBKG:IKK_alpha_*:IKK_beta_*:TNIP3

Maps_Modules
 MACROPHAGE  map
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

References
complex
PMID:17485448
TNIP3 (ABIN3‭) ‬inhibits IKK complex trough direct binding to IKBKG.
It results in inhibition of‭ ‬FNKBIA phosphorylation and
proteasomal degradation and prevents activation
of downstream‭ ‬NFkB‭ ‬signaling‭ ‬downstream of IL10.
PMID:17485448, PMID:10542212
Inhibition of NfkB signaling downstream of ABIN3 inhibits expression of IL8, IL6, TNFa, IL12p40

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IKBKG:​IKK_alpha_*:​IKK_beta_*:​TNIP3@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map + TNIP3@INNATE_IMMUNE_CELL_Cytosol map → map IKBKG:​IKK_alpha_*:​IKK_beta_*:​TNIP3@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. gTNF@INNATE_IMMUNE_CELL_Cytosol map → map rTNF@INNATE_IMMUNE_CELL_Cytosol map
  2. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol map → map rIL12p40*@INNATE_IMMUNE_CELL_Cytosol map
  3. gIL8*@INNATE_IMMUNE_CELL_Cytosol map → map rIL8*@INNATE_IMMUNE_CELL_Cytosol map
  4. gIL6@INNATE_IMMUNE_CELL_Cytosol map → map rIL6@INNATE_IMMUNE_CELL_Cytosol map