Protein HMGB1 map

Identifiers
HUGO:HMGB1

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:IMMUNE_STIMULATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS MODULE:EFFECTOR_ACTIVATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION

References
 NATURAL_KILLER  map
 DENDRITIC_CELL  map
 MACROPHAGE  map
CASCADE:IL18
CASCADE:TLR2_4
CASCADE:IFNG
CASCADE:TNF
PMID:15802534
Activated NK cells release HMGB1, which promotes inflammation and induces DC maturation.
IL-18 induces HMGB1 secretion by NK cells
PMID:12646658
IFNG upregulates protein level and secretion of HMGB1 partially via TNF induction in macrophages

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. HMGB1@INNATE_IMMUNE_CELL_Cytosol map
In compartment: TUMOR_CELL_AS_INDUCTOR
  1. HMGB1@TUMOR_CELL_AS_INDUCTOR map
In compartment: default
  1. HMGB1@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. HMGB1@INNATE_IMMUNE_CELL_Cytosol map → map HMGB1@default map
    2. HMGB1@INNATE_IMMUNE_CELL_Cytosol map → map IMMUNE_ACTIVATION@default map
    3. HMGB1@TUMOR_CELL_AS_INDUCTOR map → map HMGB1@default map
    As Catalyser:
    1. CCL4@INNATE_IMMUNE_CELL_Cytosol map → map CCL4@default map
    2. CXCR4@INNATE_IMMUNE_CELL_Cytosol map → map CXCR4@INNATE_IMMUNE_CELL_Membrane map
    3. gTGFB1@INNATE_IMMUNE_CELL_Cytosol map → map rTGFB1@INNATE_IMMUNE_CELL_Cytosol map
    4. CCR7@INNATE_IMMUNE_CELL_Cytosol map → map CCR7@INNATE_IMMUNE_CELL_Membrane map
    5. CD74:​MHC_class_II*@Endoplasmic Reticulum_Membrane map → map CD74:​MHC_class_II*@INNATE_IMMUNE_CELL_Membrane map
    6. gCLL4@INNATE_IMMUNE_CELL_Cytosol map → map rCCL4@INNATE_IMMUNE_CELL_Cytosol map
    7. rIL18@INNATE_IMMUNE_CELL_Cytosol map → map IL18@INNATE_IMMUNE_CELL_Cytosol map
    8. rIL1RN@INNATE_IMMUNE_CELL_Cytosol map → map IL1RN@INNATE_IMMUNE_CELL_Cytosol map
    9. TLR2/4*@INNATE_IMMUNE_CELL_Membrane map + LY96@INNATE_IMMUNE_CELL_Membrane map + TIRAP@INNATE_IMMUNE_CELL_Membrane map + MYD88@INNATE_IMMUNE_CELL_Membrane map + CD14@INNATE_IMMUNE_CELL_Membrane map → map CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
    10. rTLR2@INNATE_IMMUNE_CELL_Cytosol map → map TLR2@INNATE_IMMUNE_CELL_Membrane map
    11. rTLR4@INNATE_IMMUNE_CELL_Cytosol map → map TLR4@INNATE_IMMUNE_CELL_Membrane map