Protein IL18 map

Identifiers
HUGO:IL18

Maps_Modules
MODULE:RECRUITMENT_OF_IMMUNE_CELLS MODULE:INPUT_ACTIVATORS MODULE:IMMUNE_STIMULATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS MODULE:EFFECTOR_ACTIVATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION

References
 DENDRITIC_CELL  map
 NATURAL_KILLER  map
 MAST_CELL  map
CASCADE:IL18
CASCADE:TLR2_4
CASCADE:IL4
CASCADE:IL13
PMID:9469432
IL-18 has potent antitumor effects mediated by CD4+ T cells and NK cells
PMID:10679398
The role of IL-18 in innate immunity.
PMID:15802534
Exposure to HMGB1 triggers DCs to produce pro-IL-1β, and pro-IL18
PMID:14504095, PMID:14662834
IL-18 induces chemotaxis of pDC.
PMID:14662834
IL-18 had a direct migratory effect on MoDC as indicated by induction of filamentous actin polymerization and migration in Boyden chamber experiments (MoDC migrated toward an IL-18 gradient in Boyden chamber assays). In epidermal DC, IL-18 was also able to induce filamentous actin polymerization. Therefore,IL-18 might represent a novel mechanism to recruit DC to areas of inflammation.
IL-18 up-regulated most strikingly the surface expression of CD54 (ICAM1) and induces F-actin polymerization
PMID:11592085
ICAM-1 regulates the migration of dendritic cells into regional lymph nodes
PMID:15099563
Mast cells produce cytokines TNF-a, TGF-b, IFN-a, IL-1a, IL-1b, IL-5, IL-6,
IL-13, IL-16, IL-18

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IL18@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. IL18@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL18:​IL18R1:​IL18RAP:​MYD88@INNATE_IMMUNE_CELL_Membrane map
  2. IL18:​IL18R1:​IL18RAP:​IRAK4:​MYD88@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL18:​IL18R1:​IL18RAP:​MYD88@INNATE_IMMUNE_CELL_Membrane map → map RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol map
  2. IL18@INNATE_IMMUNE_CELL_Cytosol map → map IL18@default map
  3. IL18@INNATE_IMMUNE_CELL_Cytosol map → map IL18@default map
  4. IL18@INNATE_IMMUNE_CELL_Cytosol map → map IMMUNE_ACTIVATION@default map
  5. IL18@default map + IL18R1:​IL18RAP@INNATE_IMMUNE_CELL_Membrane map + MYD88@INNATE_IMMUNE_CELL_Membrane map → map IL18:​IL18R1:​IL18RAP:​MYD88@INNATE_IMMUNE_CELL_Membrane map
  6. rIL18@INNATE_IMMUNE_CELL_Cytosol map → map IL18@INNATE_IMMUNE_CELL_Cytosol map
  7. IL18@default map + IL18R1:​IL18RAP@INNATE_IMMUNE_CELL_Membrane map + MYD88@INNATE_IMMUNE_CELL_Membrane map + IRAK4@INNATE_IMMUNE_CELL_Membrane map → map IL18:​IL18R1:​IL18RAP:​IRAK4:​MYD88@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. gTBX21@INNATE_IMMUNE_CELL_Cytosol map → map rTBX21@INNATE_IMMUNE_CELL_Cytosol map
  2. HMGB1@INNATE_IMMUNE_CELL_Cytosol map → map HMGB1@default map
  3. gTGFBR2@INNATE_IMMUNE_CELL_Cytosol map → map rTGFBR2@INNATE_IMMUNE_CELL_Cytosol map
  4. gSMAD2@INNATE_IMMUNE_CELL_Cytosol map → map rSMAD2@INNATE_IMMUNE_CELL_Cytosol map
  5. gSMAD3@INNATE_IMMUNE_CELL_Cytosol map → map rSMAD3@INNATE_IMMUNE_CELL_Cytosol map
  6. gCCR7@INNATE_IMMUNE_CELL_Cytosol map → map rCCR7@INNATE_IMMUNE_CELL_Cytosol map
  7. ICAM1@INNATE_IMMUNE_CELL_Cytosol map → map ICAM1@INNATE_IMMUNE_CELL_Membrane map
  8. IRAK1@INNATE_IMMUNE_CELL_Cytosol map → map IRAK1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map