Complex IL15:IL15RA:IL2RB:IL2RG:JAK1:JAK3 map
Complex composition:

  1. IL2RG map
  2. IL2RB map
  3. IL15RA map
  4. JAK1 map
  5. IL15 map
  6. JAK3 map

IL15:​IL15RA:​IL2RB|​pho:​IL2RG:​JAK1:​JAK3@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:IL15:IL15RA:IL2RB:IL2RG:JAK1:JAK3

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:IMMUNE_STIMULATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
 NATURAL_KILLER  map
 DENDRITIC_CELL  map
CASCADE:IL15
PMID:16815076
IL-15 receptor complex contains IL15RA, IL2RG, IL2RB subunits.
IL-15-mediated signaling results in the activation of Janus kinase (JAK),
The IL-2RB chain recruits JAK1, whereas IL-2RG activates JAK3, , which in turn results in the phosphorylation and activation of STAT3 and STAT5, respectively.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL15:​IL15RA:​IL2RB|​pho:​IL2RG:​JAK1:​JAK3@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL15RA:​IL2RB:​IL2RG@INNATE_IMMUNE_CELL_Membrane map + IL15@default map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK3@INNATE_IMMUNE_CELL_Cytosol map → map IL15:​IL15RA:​IL2RB|​pho:​IL2RG:​JAK1:​JAK3@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. STAT1@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. gMICA@INNATE_IMMUNE_CELL_Cytosol map → map rMICA@INNATE_IMMUNE_CELL_Cytosol map
  3. gMICB@INNATE_IMMUNE_CELL_Cytosol map → map rMICB@INNATE_IMMUNE_CELL_Cytosol map
  4. STAT3@INNATE_IMMUNE_CELL_Cytosol map → map STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  5. STAT5*@INNATE_IMMUNE_CELL_Cytosol map → map STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  6. STAT4@INNATE_IMMUNE_CELL_Cytosol map → map STAT4|​pho@INNATE_IMMUNE_CELL_Cytosol map