Protein IL15 map

Identifiers
HUGO:IL15

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:IMMUNE_STIMULATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS MODULE:EFFECTOR_ACTIVATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION

References
 DENDRITIC_CELL  map
 NATURAL_KILLER  map
CASCADE:IFNAB
CASCADE:IL15
PMID:7523571
Interleukin 15 (IL-15) controls both the homeostasis and the peripheral activation of natural killer (NK).
Interleukin (IL) 15 activates human natural killer cells via components of the IL-2 receptor and induces cytoxic activity against tumor cells and participates in regulation of cytokine production.
PMID:17398124, PMID:19913445, PMID:17459805, PMID:21307131
Dendritic cells and macrophages prime natural killer cells by trans-presenting interleukin 15.
IL-15 is trans-presented on the surface of IL-15-producing cells in complex with the IL-15 receptor α chain (IL-15Rα).
It results in tumoricidal activity of NK cells.
PMID:14607946
DCs activate resting NK cells by expressing MHC class I-related chain A and B (MICA/B), ligands for NKG2D, in response to IFN-alpha and IL15.
IL-15- and type I IFN-mediated induction of MICA/B in healthy donors is completely inhibited when DCs are incubated in the presence of anti-IFN-alpha/betaR or anti-IL-15Ralpha, respectively, suggesting interdependent roles of these cytokines in MICA/B expression. Indeed, DCs produced IL-15 in response to type I IFN, whereas they directly produced IFN-beta, in response to IL-15, which was followed by the production of IFN-alpha.
PMID:25582338
mIL-15 DCs secreted markedly greater amounts of proinflammatory cytokines, including IL-1α, IL-1β, IL-6, TNFα, TNFβ and IFN-γ, compared with mIL-4 DCs, suggesting that mIL-15 DCs are more proinflammatory than mIL-4 DCs.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IL15@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. IL15@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL15:​IL15RA@INNATE_IMMUNE_CELL_Membrane map
  2. IL15:​IL15RA:​IL2RB|​pho:​IL2RG:​JAK1:​JAK3@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL15@INNATE_IMMUNE_CELL_Cytosol map + IL15RA@INNATE_IMMUNE_CELL_Membrane map → map IL15:​IL15RA@INNATE_IMMUNE_CELL_Membrane map
  2. IL15@default map → map Antigen_presentation@default map
  3. IL15@INNATE_IMMUNE_CELL_Cytosol map → map IMMUNE_ACTIVATION@default map
  4. IL15RA:​IL2RB:​IL2RG@INNATE_IMMUNE_CELL_Membrane map + IL15@default map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK3@INNATE_IMMUNE_CELL_Cytosol map → map IL15:​IL15RA:​IL2RB|​pho:​IL2RG:​JAK1:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  5. rIL15@INNATE_IMMUNE_CELL_Cytosol map → map IL15@INNATE_IMMUNE_CELL_Cytosol map
  6. IL15@INNATE_IMMUNE_CELL_Cytosol map → map IL15@default map
As Catalyser:
  1. TNF@INNATE_IMMUNE_CELL_Cytosol map → map TNF@default map
  2. gTBX21@INNATE_IMMUNE_CELL_Cytosol map → map rTBX21@INNATE_IMMUNE_CELL_Cytosol map
  3. gMIR27A*@INNATE_IMMUNE_CELL_Cytosol map → map arMIR27A*@INNATE_IMMUNE_CELL_Cytosol map
  4. gMIR150@INNATE_IMMUNE_CELL_Cytosol map → map arMIR150@INNATE_IMMUNE_CELL_Cytosol map
  5. IL6@INNATE_IMMUNE_CELL_Cytosol map → map IL6@default map
  6. gMIR15/16*@INNATE_IMMUNE_CELL_Cytosol map → map arMIR15/16*@INNATE_IMMUNE_CELL_Cytosol map
  7. gIL18R1@INNATE_IMMUNE_CELL_Cytosol map → map rIL18R1@INNATE_IMMUNE_CELL_Cytosol map
  8. gIL18RAP@INNATE_IMMUNE_CELL_Cytosol map → map rIL18RAP@INNATE_IMMUNE_CELL_Cytosol map
  9. gIL12RB2@INNATE_IMMUNE_CELL_Cytosol map → map rIL12RB2@INNATE_IMMUNE_CELL_Cytosol map
  10. IFNB*@INNATE_IMMUNE_CELL_Cytosol map → map IFNB*@default map
  11. gMIR223@INNATE_IMMUNE_CELL_Cytosol map → map arMIR223@INNATE_IMMUNE_CELL_Cytosol map
  12. SP1@INNATE_IMMUNE_CELL_Cytosol map → map SP1@INNATE_IMMUNE_CELL_Cytosol map
  13. PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map → map PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map
  14. ERK1/2*@INNATE_IMMUNE_CELL_Cytosol map → map ERK1/2*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  15. rDAP12*@INNATE_IMMUNE_CELL_Cytosol map → map DAP12*@INNATE_IMMUNE_CELL_Membrane map
  16. gTGFBR2@INNATE_IMMUNE_CELL_Cytosol map → map rTGFBR2@INNATE_IMMUNE_CELL_Cytosol map
  17. gSMAD3@INNATE_IMMUNE_CELL_Cytosol map → map rSMAD3@INNATE_IMMUNE_CELL_Cytosol map
  18. STAT1@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  19. trILB1@INNATE_IMMUNE_CELL_Cytosol map → map trILB1@default map
  20. IL15@INNATE_IMMUNE_CELL_Cytosol map → map IL15@default map
  21. gMICA@INNATE_IMMUNE_CELL_Cytosol map → map rMICA@INNATE_IMMUNE_CELL_Cytosol map
  22. gMICB@INNATE_IMMUNE_CELL_Cytosol map → map rMICB@INNATE_IMMUNE_CELL_Cytosol map
  23. STAT3@INNATE_IMMUNE_CELL_Cytosol map → map STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  24. rIL1A@INNATE_IMMUNE_CELL_Cytosol map → map IL1A@INNATE_IMMUNE_CELL_Cytosol map
  25. gIL2RA@INNATE_IMMUNE_CELL_Cytosol map → map rIL2RA@INNATE_IMMUNE_CELL_Cytosol map
  26. STAT5*@INNATE_IMMUNE_CELL_Cytosol map → map STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  27. IL2@INNATE_IMMUNE_CELL_Cytosol map → map IL2@default map
  28. STAT4@INNATE_IMMUNE_CELL_Cytosol map → map STAT4|​pho@INNATE_IMMUNE_CELL_Cytosol map