Identifiers
HUGO:MYL9 HUGO:MYL12A HUGO:MYL12B

Maps_Modules
MODULE:TUMOR_KILLING MODULE:EFFECTOR_ACTIVATION MODULE:EXOCYTOSIS_AND_PHAGOCYTOSIS

References
 MACROPHAGE 
CASCADE:CR3
PMID:25712372
In mammals,
three genes (MYH9, MYH10, MYH14) encode for three
non-muscle myosin-2 isoforms referred to as -2A, -2B, and -
2C, respectively. Most cells simultaneously express two or
three non-muscle myosin-2 paralogs and their splice variants
in a strictly regulated manner. Each mammalian non-muscle
myosin-2 heavy chain associates with one ELC encoded by
one of two genes (MYL6, MYL6B) and with one RLC
encoded by either MYL9, MYL12A, or MYL12B.
MLCK and ROCK phosphorylares RLC

1. RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol

1. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol
2. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@INNATE_IMMUNE_CELL_Cytosol
3. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho:​WASP*:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol

1. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@INNATE_IMMUNE_CELL_Cytosol + WASP*|​pho:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol → ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho:​WASP*:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol
2. ELC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol + RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol + MYH9|​hm2@INNATE_IMMUNE_CELL_Cytosol → ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol
3. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol → ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@INNATE_IMMUNE_CELL_Cytosol

1. Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol → Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol
2. ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5@INNATE_IMMUNE_CELL_Cytosol + WASP*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol → ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5:​WASP*|​pho@INNATE_IMMUNE_CELL_Cytosol