Identifiers
HUGO:MYL6 HUGO:MYL6B

Maps_Modules
MODULE:TUMOR_KILLING MODULE:EFFECTOR_ACTIVATION MODULE:EXOCYTOSIS_AND_PHAGOCYTOSIS

References
 MACROPHAGE 
CASCADE:CR3
PMID:25712372
In mammals,
three genes (MYH9, MYH10, MYH14) encode for three
non-muscle myosin-2 isoforms referred to as -2A, -2B, and -
2C, respectively. Most cells simultaneously express two or
three non-muscle myosin-2 paralogs and their splice variants
in a strictly regulated manner. Each mammalian non-muscle
myosin-2 heavy chain associates with one ELC encoded by
one of two genes (MYL6, MYL6B) and with one RLC
encoded by either MYL9, MYL12A, or MYL12B

1. ELC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol

1. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol
2. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@INNATE_IMMUNE_CELL_Cytosol
3. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho:​WASP*:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol

1. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@INNATE_IMMUNE_CELL_Cytosol + WASP*|​pho:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol → ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho:​WASP*:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol
2. ELC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol + RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol + MYH9|​hm2@INNATE_IMMUNE_CELL_Cytosol → ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol
3. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol → ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@INNATE_IMMUNE_CELL_Cytosol

1. Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol → Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol
2. ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5@INNATE_IMMUNE_CELL_Cytosol + WASP*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol → ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5:​WASP*|​pho@INNATE_IMMUNE_CELL_Cytosol