Identifiers
HUGO:IRF8
Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:MIRNA_TF_IMMUNOSTIMULATORY
References
MACROPHAGE
MDSC
CASCADE:GSF3
CASCADE:GSF2
CASCADE:IFNG
CASCADE:TLR2_4
PMID:24091328
(a) Irf8-deficient mice generated myeloid populations highly homologous to tumor-induced MDSCs with respect to phenotype, function, and gene expression profiles; (b) IRF-8 overexpression in mice attenuated MDSC accumulation and enhanced immunotherapeutic efficacy; (c) the MDSC-inducing factors G-CSF and GM-CSF facilitated IRF-8 downregulation via STAT3- and STAT5-dependent pathways; and (d) IRF-8 levels in MDSCs of breast cancer patients declined with increasing MDSC frequency, implicating IRF-8 as a negative regulator in human MDSC biology.
IRF-8 levels are depressed in MDSCs of breast cancer patients.
PMID:12417340
IRF-8/ICSBP and IRF-1 cooperatively stimulate mouse IL-12 p40 promoter activity in macrophages.
PMID:16597464
IRF-8 and IRF-1 are the target genes in activated macrophages.
The expression levels of CXCL16, H28, IL-17R, LIF, MAP4K4, MMP9, MYC, PCDH7, PML, and SOCS7 were significantly increased in macrophages
extracted form WT mice (black columns) following activation
for 4 h with IFNG and LPS. However, no changes in the expression of these genes were observed in cells extracted from IRF-8,
as well as from IRF-1 null mice.
PMID:10734131
PU.1 (SPI1) together with IRF8 relulates TLR4 expression in myeloid cells
→ rCXCL16@INNATE_IMMUNE_CELL_Cytosol
→ rIL12p40*@INNATE_IMMUNE_CELL_Cytosol
→ rMMP9@INNATE_IMMUNE_CELL_Cytosol
→ rTLR4@INNATE_IMMUNE_CELL_Cytosol
→ rMYC@INNATE_IMMUNE_CELL_Cytosol