BRCA1:CTIP*

Complex BRCA1:CTIP*

Complex composition:

Identifiers
NAME:BRCA1:CTIP*

Maps_Modules
dnarepair

References
This complex exists only in S-G2 phase and facilitates shift from A_NHEJ to HR in cell cycle-dependent manner
PMID:15485915, PMID:19357644
d_re121( dnarepair ):
The shift from C_NHEJ to HR is regulated by the CtIP and BRCA1. CDK1-dependent phosphorylation of CtIP regulates the shift: PMID:19357644
PMID:15485915
d_re113:( dnarepair ) PMID:18171670
d_re120( dnarepair ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141

Confidence
REF=5 FUNC=5

Modifications:
Participates in complexes:
In compartment: default

BRCA1|S988_pho|S1387_pho|S1423_pho|S1497_pho|S1524_pho:CTIP*|emp|S372_pho|T847_pho|S267_pho|BRCA1-dep_ubi@default

Participates in reactions:
As Reactant or Product:

As Catalyser: