Identifiers
NAME:BRCA1:CTIP*:MRE11*:NBS1*:PARP1:PARP2:RAD50
Maps_Modules
dnarepair
References
For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ
PMID:20021983
PARP1 and PARP2 in HR
PMID:22469522, PMID:196269035
d_re113:( dnarepair ) PMID:18171670
d_re80( dnarepair ):
The complex MRN:BRCA1:phos-Ub-CtIP is central in the shift toward HR, because it activates resection for HR and blocks Ku70/80 of C_NHEJ:
PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983
d_re114( dnarepair ):
PMID:18171670, PMID:20064462
For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928
The complex BRCA2:FANCC:FANCG:XRCC3 activates HR:
PMID:18212739
For role of BLM:TOP3:RMI1 complex in the HR resection step:
PMID:19490890
For inhibition of HR by RECQ5:
PMID:19270065
For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation:
PMID:15655342, PMID:15549137, PMID:15496928
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
PMID:18001825
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833
Confidence
REF=5 FUNC=4
+ MRE11*:NBS1*|S343_pho:RAD50@default + PARP1|PolyADPribose_unk|pho:PARP2|unk|pho@default → BRCA1:CTIP*|emp|S372_pho|T847_pho|S267_pho|BRCA1-dep_ubi:MRE11*:NBS1*|S343_pho:PARP1|PolyADPribose_unk|pho:PARP2|unk|pho:RAD50@default