Catalysis

1. SMC5:​SMC6@default
2. BLM:​EXO1@Nucleus
3. BRCA2:​FANCC:​FANCG|​S7_pho:​XRCC3@default
4. SMC1*|​S957_pho:​SMC3|​S1083_pho@default
5. BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default
6. ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default
7. S phase@default
8. G2 phase@default

Inhibition

1. RECQL5 @default
2. PCNA|​K164_don|​K127_don@default
3. TP53BP1@default

Modulation

1. POLI@default
2. MDC1|​pho:​RNF8@default
3. H2AFX|​S139_pho|​ubi:​MDC1|​pho@default

Unknown_catalysis

1. BLM:​RMI1:​TOP3A@default

References
PMID:18171670, PMID:20064462
For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928
The complex BRCA2:FANCC:FANCG:XRCC3 activates HR:
PMID:18212739
For role of BLM:TOP3:RMI1 complex in the HR resection step:
PMID:19490890
For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ:
PMID:20021983
For inhibition of HR by RECQ5:
PMID:19270065
For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation:
PMID:15655342, PMID:15549137, PMID:15496928
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
PMID:18001825
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833

Confidence
REF=5 FUNC=4