Identifiers
NAME:H2AFX:MDC1
Maps_Modules
dnarepair
dnarepair
References
PMID:17303408, PMID:16377563
d_re114( dnarepair ):
PMID:18171670, PMID:20064462
For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928
The complex BRCA2:FANCC:FANCG:XRCC3 activates HR:
PMID:18212739
For role of BLM:TOP3:RMI1 complex in the HR resection step:
PMID:19490890
For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ:
PMID:20021983
For inhibition of HR by RECQ5:
PMID:19270065
For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation:
PMID:15655342, PMID:15549137, PMID:15496928
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
PMID:18001825
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833
d_re136( dnarepair ):
Regulation of HR DNA repair foci formation regulation by UBc13:
PMID:17349954
For role of SMARCAL1/RPA in stalled relication fork repair and in the homologous recombination:
PMID:19841479, PMID:19793861, PMID:19793862
MCM8*/MCM9* colocolize at RAD51 filament and reqired for interstrand crosslinks repair
PMID:22771115
Confidence
REF=5 FUNC=5
+ MDC1|pho@default → H2AFX|S139_pho|ubi:MDC1|pho@default
+ H2AFX|S139_pho|ubi:MDC1|pho@default → ATM|S1981_pho|S367_pho|S1893_pho:H2AFX|S139_pho|ubi:MDC1|pho:MRE11*:NBS1*|S343_pho:RAD50@default