Identifiers
NAME:MDC1:RNF8
Maps_Modules
dnarepair
dnarepair
dnarepair
References
PMID:18006705
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR
PMID:18001825
Complex RNF8:MDC1 ubiquitinates Ku80 and causes it's dissociation from DNA and degradation.This bring to shift from C_NHEJ to HR
PMID:18001825, PMID:18678709
d_re114( dnarepair ):
PMID:18171670, PMID:20064462
For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928
The complex BRCA2:FANCC:FANCG:XRCC3 activates HR:
PMID:18212739
For role of BLM:TOP3:RMI1 complex in the HR resection step:
PMID:19490890
For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ:
PMID:20021983
For inhibition of HR by RECQ5:
PMID:19270065
For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation:
PMID:15655342, PMID:15549137, PMID:15496928
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833
d_re129( dnarepair ):
PMID:18809224
d_re147( dnarepair ):
PMID:17303408
Confidence
REF=5 FUNC=5