Identifiers
mediator of DNA-damage checkpoint 1
HUGO:MDC1 HGNC:21163 ENTREZ:9656 UNIPROT:Q14676 GENECARDS:MDC1 REACTOME:110541 KEGG:9656 ATLASONC:GC_MDC1 WIKI:MDC1

Maps_Modules
 apoptosis 
 dnarepair 
 dnarepair 
 dnarepair 
 dnarepair 

References
PMID:18006705, PMID:17303408, PMID:18583988, PMID:18590585, PMID:17660363, PMID:7575488, PMID:15279786
For S-phase checkpoint
PMID:15459660, PMID:12607003, PMID:18583988, PMID:9407949, PMID:18678890

References
d_re148( dnarepair  ):
PMID:18006705
PMID:18583988

References
d_re148( dnarepair  ):
PMID:18006705
PMID:18583988
d_re149:( dnarepair  ) PMID:17303408, PMID:16377563

1. MDC1@default
2. MDC1|​pho@default

1. MDC1|​pho:​RNF8@default
2. H2AFX|​S139_pho|​ubi:​MDC1|​pho@default
3. ATM|​S1981_pho|​S367_pho|​S1893_pho:​H2AFX|​S139_pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default

1. MDC1@default → MDC1|​pho@default
2. H2AFX|​S139_pho|​ubi@default + MDC1|​pho@default → H2AFX|​S139_pho|​ubi:​MDC1|​pho@default
3. RNF8@default + MDC1|​pho@default → MDC1|​pho:​RNF8@default
4. ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default + H2AFX|​S139_pho|​ubi:​MDC1|​pho@default → ATM|​S1981_pho|​S367_pho|​S1893_pho:​H2AFX|​S139_pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default

1. gHR_DNA_st1*@Nucleus → gHR_DNA_st2*@Nucleus
2. S phase@default → G2 phase@default
3. G2 phase@default → M phase@default
4. Ku80*@default → Ku80*|​ubi@default
5. gHR_DNA_st2*@Nucleus → gHR_DNA_st3*@Nucleus
6. H2AFX|​S139_pho@default → H2AFX|​S139_pho|​ubi@default
7. ATM@default → ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@default
8. CHEK2@default → CHEK2|​pho|​active@default
9. Ku70*@default + Ku80*@default → Ku70*:​Ku80*@Nucleus
10. DNA-PK*@default → DNA-PK*|​pho@default