Protein H2AFX map

Identifiers
H2A histone family, member X
HUGO:H2AFX HGNC:4739 ENTREZ:3014 UNIPROT:P16104 GENECARDS:H2AFX REACTOME:56152 KEGG:3014 ATLASONC:H2AFXID40783ch11q23 WIKI:H2AFX

Maps_Modules
 apoptosis  map
 dnarepair  map
 dnarepair  map
 survival  map

References
PMID:9488723, PMID:19772495, PMID:17303408
For S-phase checkpoint
PMID:15459660, PMID:12607003

H2AFX|​S139_pho|​ubi@default

References
d_re147( dnarepair  map ):
PMID:18006705
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
PMID:18001825
PMID:17303408
d_re149:( dnarepair  map ) PMID:17303408, PMID:16377563
d_re166( dnarepair  map ):
Fanconi recognition complex as FA core complex recruits NER, HR, TLS proteins that collectively repair the ICL. If Fanconi proteins participating in the recognition are dysactivated, there is no any other mechanism to recognize ILSs, therefore, even if NER, HR and TLS are correct, they will not perform the repair without core Fanconi proteins.
PMID:19686080

H2AFX|​S139_pho@default

References
d_re90( dnarepair  map ):
PMID:9488723, PMID:19772495
PMID:17303408
d_re92:( dnarepair  map ) PMID:16310392
d_re147( dnarepair  map ):
PMID:18006705
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
PMID:18001825

H2AFX@default

References
d_re92:( dnarepair  map ) PMID:16310392
d_re90( dnarepair  map ):
PMID:9488723, PMID:19772495
PMID:17303408

Modifications:
In compartment: default
  1. H2AFX@default map
  2. H2AFX|​S139_pho@default map
  3. H2AFX|​S139_pho|​ubi@default map
Participates in complexes:
In compartment: default
  1. H2AFX:​PARP1@default map
  2. H2AFX|​S139_pho|​ubi:​MDC1|​pho@default map
  3. ATM|​S1981_pho|​S367_pho|​S1893_pho:​H2AFX|​S139_pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  4. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  5. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
Participates in reactions:
As Reactant or Product:
  1. H2AFX|​S139_pho@default map → map H2AFX|​S139_pho|​ubi@default map
  2. H2AFX|​S139_pho|​ubi@default map + MDC1|​pho@default map → map H2AFX|​S139_pho|​ubi:​MDC1|​pho@default map
  3. FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default map + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map + BRCA2@default map + NBS1*|​S343_pho@default map + RAD51@default map + PCNA@default map + H2AFX|​S139_pho|​ubi@default map + TIP60*@default map → map BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  4. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map → map BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  5. H2AFX@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map → map H2AFX:​PARP1@default map
  6. H2AFX@default map → map H2AFX|​S139_pho@default map
  7. H2AFX|​S139_pho@default map → map H2AFX@default map
  8. ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map + H2AFX|​S139_pho|​ubi:​MDC1|​pho@default map → map ATM|​S1981_pho|​S367_pho|​S1893_pho:​H2AFX|​S139_pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
As Catalyser:
  1. gHR_DNA_st1*@Nucleus map → map gHR_DNA_st2*@Nucleus map
  2. G1 phase@default map → map S phase@default map
  3. S phase@default map → map G2 phase@default map
  4. G2 phase@default map → map M phase@default map
  5. gHR_DNA_st2*@Nucleus map → map gHR_DNA_st3*@Nucleus map
  6. gFanconi_DNA_st4*@Nucleus map → map gHR_DNA_st2*@Nucleus map
  7. ATM@default map → map ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@default map
  8. CHEK2@default map → map CHEK2|​pho|​active@default map
  9. Ku70*@default map + Ku80*@default map → map Ku70*:​Ku80*@Nucleus map
  10. DNA-PK*@default map → map DNA-PK*|​pho@default map