Protein eIF4E
The biological function of eIF4E phosphorylation has been contreversial. Some studies report that eIF4E Ser209 phosphorylation enhance translation in general, while others conclude that Ser209 has no effect, or even reduces translation.
Recently, Ser209 phosphorylation site has been reported essential for
eIF4E's oncogenic action in mice.
PMID:2318815
PMID:2105935
PMID:9654048
PMID:11368785
PMID:11606200
PMID:11723111
PMID:18055695

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Modifications:
In compartment: Cell membrane

1. eIF4E@Cell membrane

Participates in complexes:
In compartment: Cell membrane

1. eIF4E:​m7GTP:​mRNA@Cell membrane
2. 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane
3. eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
4. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​eIF4E:​m7GTP:​mRNA@Cell membrane
5. SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
6. eIF4A:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
7. Mnk1/2:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
8. Mnk1/2:​eIF4E|​S209_pho:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
9. 4EBP-1:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
10. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
11. eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
12. Raptor|​S722_pho|​S719_pho|​S721_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
13. 4EBP-1:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA@Cell membrane
14. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
15. ?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
16. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
17. eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
18. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
19. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
20. PABP:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
21. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
22. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
23. PABP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane

Participates in reactions:
As Reactant or Product:

1. eIF4E@Cell membrane + m7GTP:​mRNA@Cell membrane → eIF4E:​m7GTP:​mRNA@Cell membrane
2. eIF4E:​m7GTP:​mRNA@Cell membrane + eIF4G|​S1108_pho|​S1148_pho|​S1192_pho@Cell membrane → eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
3. eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane + eIF4A@Cell membrane → eIF4A:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
4. eIF4A:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane + eIF4B|​S422_pho@Cell membrane → eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
5. eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane + eIF3@Cell membrane → eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
6. PABP@Cell membrane + eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane → PABP:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
7. 4EBP-1@Cell membrane + eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane
8. Mnk1/2:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane → Mnk1/2:​eIF4E|​S209_pho:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
9. eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane + Mnk1/2@Cell membrane → Mnk1/2:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
10. S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3@Cell membrane + 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA@Cell membrane
11. FKBP38:​GTP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​Rheb:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + 4EBP-1:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
12. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
13. Raptor|​S722_pho|​S719_pho|​S721_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → PABP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
14. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → Raptor|​S722_pho|​S719_pho|​S721_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
15. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → Raptor|​S722_pho|​S719_pho|​S721_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane + S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho|​active@Cell membrane
16. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
17. PABP:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane + GDP:​eIF2_alpha:​eIF2_beta:​eIF2_gamma:​eIF3:​rpS6/40S subunit|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cell membrane → 5'cap-eIF4F-eIF4B-eIF3-PABP:​eIF2-GTP_Met-tRNAi_40S@Cell membrane
18. PABP:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​eIF3:​eIF4A:​eIF4B|​S422_pho:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 5'cap-eIF4F-eIF4B-eIF3-PABP:​eIF2-GTP_Met-tRNAi_40S@Cell membrane
19. 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​eIF4E:​m7GTP:​mRNA@Cell membrane
20. 4EBP-1:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
21. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​eIF4E:​m7GTP:​mRNA@Cell membrane → eIF4E:​m7GTP:​mRNA@Cell membrane + 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
22. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane + 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
23. SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → mRNA translation@Cell membrane
24. SF2/ASF:​mTOR@Cell membrane + 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
25. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​eIF4E:​m7GTP:​mRNA@Cell membrane
26. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
27. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → ?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane + 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho@Cell membrane
28. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​eIF4E:​m7GTP:​mRNA@Cell membrane + ?:​PP2A:​SF2/ASF@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
29. mTOR@Cell membrane + 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
30. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
31. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
32. ?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → mRNA translation@Cell membrane

As Catalyser:

1. eIF4E:​m7GTP:​mRNA@Cell membrane + eIF4G|​S1108_pho|​S1148_pho|​S1192_pho@Cell membrane → eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
2. Mnk1/2:​eIF4E:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane → Mnk1/2:​eIF4E|​S209_pho:​eIF4G|​S1108_pho|​S1148_pho|​S1192_pho:​m7GTP:​mRNA@Cell membrane
3. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
4. 4EBP-1:​Raptor|​S722_pho|​S719_pho|​S721_pho|​S863_pho:​S6K1|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​m7GTP:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​Raptor|​S722_pho|​S719_pho|​S721_pho:​S6K1|​T389_pho|​S371_pho|​S411_pho|​S418_pho|​T421_pho|​S424_pho|​S17_pho:​eIF3:​eIF4E:​mRNA:​mTOR|​S2481_pho|​S1261_pho@Cell membrane
5. 4EBP-1:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
6. 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane → 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA@Cell membrane
7. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane
8. 4EBP-1:​?:​PP2A:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane → 4EBP-1|​T37_pho|​T46_pho|​S65_pho|​S70_pho:​?:​PP2A|​pho:​SF2/ASF:​eIF4E:​m7GTP:​mRNA:​mTOR@Cell membrane