Identifiers
HUGO:IKBKG

Maps_Modules
 MACROPHAGE 
 MDSC 
 DENDRITIC_CELL 
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
CASCADE:STING
CASCADE:TLR2_4

References
PMID:17485448
TNIP3 (ABIN3‭) ‬inhibits IKK complex trough direct binding to IKBKG.
It results in inhibition of‭ ‬FNKBIA phosphorylation and
proteasomal degradation and prevents activation
of downstream‭ ‬NFkB‭ ‬signaling‭ ‬downstream of IL10.

1. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol
2. IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol
3. IKBKG:​IKK_alpha_*:​IKK_beta_*:​TNIP3@INNATE_IMMUNE_CELL_Cytosol

1. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol → IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol
2. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol + TNIP3@INNATE_IMMUNE_CELL_Cytosol → IKBKG:​IKK_alpha_*:​IKK_beta_*:​TNIP3@INNATE_IMMUNE_CELL_Cytosol

1. gTNF@INNATE_IMMUNE_CELL_Cytosol → rTNF@INNATE_IMMUNE_CELL_Cytosol
2. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol → rIL12p40*@INNATE_IMMUNE_CELL_Cytosol
3. gIL8*@INNATE_IMMUNE_CELL_Cytosol → rIL8*@INNATE_IMMUNE_CELL_Cytosol
4. gIL6@INNATE_IMMUNE_CELL_Cytosol → rIL6@INNATE_IMMUNE_CELL_Cytosol
5. STAT1@INNATE_IMMUNE_CELL_Cytosol → STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
6. IkB*:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol → IkB*|​pho:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol
7. IkB*:​NFKB1_p50*:​RELB@INNATE_IMMUNE_CELL_Cytosol → IL10RA:​IkB*|​pho:​NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol
8. IkB*:​NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol → IkB*|​pho:​NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol
9. MAP3K8:​NFKB1_p105*:​TNIP2@INNATE_IMMUNE_CELL_Cytosol → NFKB1_p105*|​pho@INNATE_IMMUNE_CELL_Cytosol + MAP3K8@INNATE_IMMUNE_CELL_Cytosol + TNIP2@INNATE_IMMUNE_CELL_Cytosol