Protein IRF1 map

Identifiers
HUGO:IRF1

Maps_Modules
 MACROPHAGE  map
 NATURAL_KILLER  map
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:MIRNA_TF_IMMUNOSTIMULATORY
CASCADE:IL2
CASCADE:TNF
CASCADE:IFNAB
CASCADE:IFNG
CASCADE:TLR2_4

References
PMID:11399519
STAT1, IRF1 and NF-kB interact with NOS2 promoter and cooperatively activate NOS2 expression in macrophages downstteam of IFNG.
PMID:10820262
Probably IFNG induces SOCS1 expressiov via IRF1 upregulation downstream of STAT1
PMID:18345002
TNF induces IRF1 expression both through TNFR1 and TNFR2.
TNF induced IFNB expression through IRF1
PMID:12417340
IRF-8/ICSBP and IRF-1 cooperatively stimulate mouse IL-12 p40 promoter activity in macrophages.
IRF-1 can be acetylated by p300. p300 is recruited to the IL-12p40 promoter depending on both ICSBP and IRF-1
and acts as coactivator.
PMID:16597464
IRF-8 and IRF-1 are the target genes in activated macrophages.
The expression levels of CXCL16, H28, IL-17R, LIF, MAP4K4, MMP9, MYC, PCDH7, PML, and SOCS7 were significantly increased in macrophages
extracted form WT mice following activation
for 4 h with IFNG and LPS. However, no changes in the expression of these genes were observed in cells extracted from IRF-8,

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IRF1@INNATE_IMMUNE_CELL_Cytosol map
  2. IRF1|​ace@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rIRF1@INNATE_IMMUNE_CELL_Cytosol map → map IRF1@INNATE_IMMUNE_CELL_Cytosol map
    2. IRF1@INNATE_IMMUNE_CELL_Cytosol map → map IRF1|​ace@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. gIDO1@INNATE_IMMUNE_CELL_Cytosol map → map rIDO1@INNATE_IMMUNE_CELL_Cytosol map
    2. gCXCL16@INNATE_IMMUNE_CELL_Cytosol map → map rCXCL16@INNATE_IMMUNE_CELL_Cytosol map
    3. gNOS2@INNATE_IMMUNE_CELL_Cytosol map → map rNOS2@INNATE_IMMUNE_CELL_Cytosol map
    4. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol map → map rIL12p40*@INNATE_IMMUNE_CELL_Cytosol map
    5. gIFNB*@INNATE_IMMUNE_CELL_Cytosol map → map rINFB*@INNATE_IMMUNE_CELL_Cytosol map
    6. gMMP9@INNATE_IMMUNE_CELL_Cytosol map → map rMMP9@INNATE_IMMUNE_CELL_Cytosol map
    7. gCIITA@INNATE_IMMUNE_CELL_Cytosol map → map rCIITA@INNATE_IMMUNE_CELL_Cytosol map
    8. gSOCS1@INNATE_IMMUNE_CELL_Cytosol map → map rSOCS1@INNATE_IMMUNE_CELL_Cytosol map
    9. gMYC@INNATE_IMMUNE_CELL_Cytosol map → map rMYC@INNATE_IMMUNE_CELL_Cytosol map
    10. gTRAIL*@INNATE_IMMUNE_CELL_Cytosol map → map rTRAIL*@INNATE_IMMUNE_CELL_Cytosol map