Protein TRADD map

Identifiers
HUGO:TRADD

Maps_Modules
 MACROPHAGE  map
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
CASCADE:TNF

References
PMID:14730360
TRADD is an adaptor molecule important for transducing signals from TNFR1. After binding of TNF, TRADD is recruited to TNFR1 and interacts with the cytoplasmic death domain region of TNFR1 through homotypic interactions. The TNFR1-TRADD complex serves as scaffolding for the recruitment of other signaling molecules that mediate the downstream actions of TNF.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. TRADD@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane map
  2. FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane map → map FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@INNATE_IMMUNE_CELL_Membrane map
  2. TNF@default map + TNFR1*@INNATE_IMMUNE_CELL_Membrane map + TRADD@INNATE_IMMUNE_CELL_Membrane map + TRAF2@INNATE_IMMUNE_CELL_Membrane map + RIPK1@INNATE_IMMUNE_CELL_Membrane map + FADD@INNATE_IMMUNE_CELL_Membrane map → map FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. MAP3K7@INNATE_IMMUNE_CELL_Cytosol map + TAB2@INNATE_IMMUNE_CELL_Cytosol map + TAB3@INNATE_IMMUNE_CELL_Cytosol map → map (MAP3K7:​TAB2:​TAB3)|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol map
  3. JNK*@INNATE_IMMUNE_CELL_Cytosol map → map JNK*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  4. p38*@INNATE_IMMUNE_CELL_Cytosol map → map p38*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map