Identifiers
HUGO:TRAF2

Maps_Modules
 MACROPHAGE 
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
CASCADE:TNF

References
PMID:21232017, PMID:21133840, PMID:18641653
TNF induces TRADD-dependent and RIPK1-dependent recruitment of TRAF2 to TNFR1.
TNFR2 interacts with TRAF2 and TRAF1.
PMID:24378531
TNF via TNFR2  induces TRAF2 degradation.

1. TRAF2@INNATE_IMMUNE_CELL_Membrane

1. TNF:​TNFR2*:​TRAF1:​TRAF2@INNATE_IMMUNE_CELL_Membrane
2. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane
3. FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@INNATE_IMMUNE_CELL_Membrane

1. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane → FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@INNATE_IMMUNE_CELL_Membrane
2. TNF@default + TNFR1*@INNATE_IMMUNE_CELL_Membrane + TRADD@INNATE_IMMUNE_CELL_Membrane + TRAF2@INNATE_IMMUNE_CELL_Membrane + RIPK1@INNATE_IMMUNE_CELL_Membrane + FADD@INNATE_IMMUNE_CELL_Membrane → FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@INNATE_IMMUNE_CELL_Membrane
3. TNF@default + TNFR2*@INNATE_IMMUNE_CELL_Membrane + TRAF1@INNATE_IMMUNE_CELL_Membrane + TRAF2@INNATE_IMMUNE_CELL_Membrane → TNF:​TNFR2*:​TRAF1:​TRAF2@INNATE_IMMUNE_CELL_Membrane
4. TRAF2@INNATE_IMMUNE_CELL_Membrane → degraded

1. MAP3K7@INNATE_IMMUNE_CELL_Cytosol + TAB2@INNATE_IMMUNE_CELL_Cytosol + TAB3@INNATE_IMMUNE_CELL_Cytosol → (MAP3K7:​TAB2:​TAB3)|​active@INNATE_IMMUNE_CELL_Cytosol
2. gIRF1@INNATE_IMMUNE_CELL_Cytosol → rIRF1@INNATE_IMMUNE_CELL_Cytosol
3. TRAF2@INNATE_IMMUNE_CELL_Membrane → degraded
4. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol → IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol
5. JNK*@INNATE_IMMUNE_CELL_Cytosol → JNK*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
6. p38*@INNATE_IMMUNE_CELL_Cytosol → p38*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol