Protein FOS map

Identifiers
HUGO:FOS

Maps_Modules
 DENDRITIC_CELL  map
 NATURAL_KILLER  map
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:MIRNA_TF_IMMUNOSUPPRESSIVE
CASCADE:Fc_gamma_RIII

References
PMID:21385848, PMID:22634314
c-Fos downregulates mRNA expression of TNF, IL6, IL1B, IL12p40. IL12p35, IL23a
Additionally Fos downregulates CD86, CD40 surface expression, IL2 secretion and Tcell activation.
PMID:22634314
Expression of IL-10 was enhanced in DC overexpressed Fos.
PMID:16394015 PMID:19667062
TPL-2 ERK pathway induces Fos expression in macrophages ()
PMID:16394015 , PMID:19667062, PMID:15067049
Fos inhibits the expression of IL-12 p40 and IFNB and upregulates IL10 production downstream of FOS in macrophages and DCs
PMID:9064320
CD16-induced ERK activation provides TNFA expression in NK cells.
MEK/ERK cascade induces AP1(c-fos) phosphorylation downstream of CD16

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. FOS@INNATE_IMMUNE_CELL_Cytosol map
  2. FOS|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. FOS@INNATE_IMMUNE_CELL_Cytosol map → map FOS|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
    2. rFOS@INNATE_IMMUNE_CELL_Cytosol map → map FOS@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. gTGFB1@INNATE_IMMUNE_CELL_Cytosol map → map rTGFB1@INNATE_IMMUNE_CELL_Cytosol map
    2. gIL10@INNATE_IMMUNE_CELL_Cytosol map → map rIL10@INNATE_IMMUNE_CELL_Cytosol map
    3. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol map → map rIL12p40*@INNATE_IMMUNE_CELL_Cytosol map
    4. gIFNB*@INNATE_IMMUNE_CELL_Cytosol map → map rINFB*@INNATE_IMMUNE_CELL_Cytosol map