Protein BCL3 
Identifiers
HUGO:BCL3
Maps_Modules
MACROPHAGE
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:MIRNA_TF_IMMUNOSUPPRESSIVE
CASCADE:IL10
References
PMID:15465827
BCL3 inhibits expression of IL1A, IL1B,TNF and positively regulates
IL-10 expression. BCL3 forms complex with HDAC1 and
repression of the TNF promoter by BCL3
requires Histone Deacetylase Activity.
PMID:12907458
Bcl-3 interacted with NF-κB p50,
both Bcl-3 and p50 were recruited to the TNF promoter,
BCL3 and p50 NFkB recruitment to TNF promoter
prevents binding of p65/p50 NFkB heterodimers
to TNF promotor and suppresses TNF expression
downstream of IL10.
Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
- BCL3@INNATE_IMMUNE_CELL_Cytosol
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
- BCL3:HDAC1@INNATE_IMMUNE_CELL_Cytosol
- BCL3:NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol
Participates in reactions:
As Reactant or Product:- rBCL3@INNATE_IMMUNE_CELL_Cytosol → BCL3@INNATE_IMMUNE_CELL_Cytosol
- BCL3@INNATE_IMMUNE_CELL_Cytosol + HDAC1@INNATE_IMMUNE_CELL_Cytosol → BCL3:HDAC1@INNATE_IMMUNE_CELL_Cytosol
- BCL3@INNATE_IMMUNE_CELL_Cytosol + NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol → BCL3:NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol
As Catalyser:- gTNF@INNATE_IMMUNE_CELL_Cytosol → rTNF@INNATE_IMMUNE_CELL_Cytosol
- gIL10@INNATE_IMMUNE_CELL_Cytosol → rIL10@INNATE_IMMUNE_CELL_Cytosol
- gIL1B@INNATE_IMMUNE_CELL_Cytosol → rIL1B@INNATE_IMMUNE_CELL_Cytosol
- gIL1A@INNATE_IMMUNE_CELL_Cytosol → rIL1A@INNATE_IMMUNE_CELL_Cytosol