Complex ATM:CTIP*:MRE11*:NBS1*:RAD50:WRN map
Complex composition:

  1. MRE11* map
  2. RAD50 map
  3. ATM map
  4. NBS1* map
  5. CTIP* map
  6. WRN map

ATM|​S1981_pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​MRE11*:​NBS1*|​S343_pho:​RAD50:​WRN@Nucleus

Identifiers
NAME:ATM:CTIP*:MRE11*:NBS1*:RAD50:WRN

Maps_Modules
 dnarepair  map

References
PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292
For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ):
PMID:21376743, PMID:24050180, PMID:22743550
Activation of WRN in cancers
PMID:18524993
http://www.intechopen.com/download/get/type/pdfs/id/22156
http://www.intechopen.com/download/get/type/pdfs/id/19301
d_re122( dnarepair  map ):
PMID:20064462,
MRN complex in A_NHEJ: PMID:19362533, PMID:19654615, PMID:19892829
d_re105( dnarepair  map ):
PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224
For inhibition of A_NHEJ by DNA-PKs:
PMID:15211575
For stimulation of A_NHEJ by PARP1:
PMID:15498778, PMID:19362533, PMID:24050180
For role of MRN complex in A_NHEJ:
PMID:19654615, PMID:19892829
BLM inhibits A_NHEJ (alt_NHEJ):
PMID:24089143
PMID:24095737

Confidence
REF=5 FUNC=5

Modifications:
Participates in complexes:
In compartment: Nucleus
  1. ATM|​S1981_pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​MRE11*:​NBS1*|​S343_pho:​RAD50:​WRN@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map + CTIP*|​emp@default map + WRN@Nucleus map → map ATM|​S1981_pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​MRE11*:​NBS1*|​S343_pho:​RAD50:​WRN@Nucleus map
As Catalyser:
  1. gA_NHEJ_DNA_st1*@Nucleus map → map gA_NHEJ_DNA_st2*@Nucleus map