Protein RAD50 map

Identifiers
RAD50 homolog (S. cerevisiae)
HUGO:RAD50 HGNC:9816 ENTREZ:10111 UNIPROT:Q92878 GENECARDS:RAD50 REACTOME:75159 KEGG:10111 ATLASONC:GC_RAD50 WIKI:RAD50

Maps_Modules
 apoptosis  map
 dnarepair  map
 dnarepair  map
 dnarepair  map
 dnarepair  map

References
PMID:18809224, PMID:18584027, PMID:19772495, PMID:18087292, PMID:20723763
For S-phase checkpoint
PMID:15459660, PMID:11850621, PMID:19793801, PMID:12607003
For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ):
PMID:21376743, PMID:24050180, PMID:22743550

RAD50@default

References
d_re91( dnarepair  map ):
MRN complex:
PMID:16531125, PMID:17303408
Double strand breaks sensor.
MRN complex association is a first event after the DNA damage.

Modifications:
In compartment: default
  1. RAD50@default map
Participates in complexes:
In compartment: Nucleus
  1. ATM|​S1981_pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​MRE11*:​NBS1*|​S343_pho:​RAD50:​WRN@Nucleus map
In compartment: default
  1. MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  2. ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  3. ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  4. ATM|​S1981_pho|​S367_pho|​S1893_pho:​H2AFX|​S139_pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  5. BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default map
Participates in reactions:
As Reactant or Product:
  1. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@default map → map BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default map
  2. ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map + CTIP*|​emp@default map + WRN@Nucleus map → map ATM|​S1981_pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​MRE11*:​NBS1*|​S343_pho:​RAD50:​WRN@Nucleus map
  3. FANCD2|​K561_ubi|​pho@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + ATR|​pho|​active@Nucleus map → map ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  4. MRE11*@default map + RAD50@default map + NBS1*|​S343_pho@default map → map MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  5. ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map + H2AFX|​S139_pho|​ubi:​MDC1|​pho@default map → map ATM|​S1981_pho|​S367_pho|​S1893_pho:​H2AFX|​S139_pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  6. ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map → map ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
As Catalyser:
  1. gA_NHEJ_DNA_st1*@Nucleus map → map gA_NHEJ_DNA_st2*@Nucleus map
  2. gHR_DNA_st1*@Nucleus map → map gHR_DNA_st2*@Nucleus map
  3. G1 phase@default map → map S phase@default map
  4. S phase@default map → map G2 phase@default map
  5. G2 phase@default map → map M phase@default map
  6. gFanconi_DNA_st2*@Nucleus map → map gFanconi_DNA_st3*@Nucleus map
  7. gFanconi_DNA_st3*@Nucleus map → map gFanconi_DNA_st4*@Nucleus map
  8. gFanconi_DNA_st4*@Nucleus map → map gHR_DNA_st2*@Nucleus map
  9. FANCD2@default map → map FANCD2|​pho@default map
  10. gSSA_DNA_st1*@Nucleus map → map gSSA_DNA_st2*@Nucleus map
  11. ATM@default map → map ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@default map
  12. CHEK2@default map → map CHEK2|​pho|​active@default map
  13. Ku70*@default map + Ku80*@default map → map Ku70*:​Ku80*@Nucleus map
  14. gC_NHEJ_DNA_st1*@Nucleus map → map gC_NHEJ_DNA_st2*@Nucleus map
  15. DNA-PK*@default map → map DNA-PK*|​pho@default map
  16. H2AFX@default map → map H2AFX|​S139_pho@default map